TY - JOUR
T1 - Multiple Sclerosis Severity Score
T2 - Concept and applications
AU - Kister, Ilya
AU - Kantarci, Orhun H.
N1 - Publisher Copyright:
© The Author(s), 2020.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - Severity score represents disease duration–adjusted mean rank of disability in multiple sclerosis (MS) patients from the reference population. This measure allows one to compare the relative rates of disease progression among patients, patient subgroups, and across epochs, which opens up new question of what accounts for the observed differences in severity, and can be used to assess correlation between disease severity and clinical, radiologic, immunologic, genetic, and environmental variables of interest. Severity score can also prove useful for developing prognostic tools in MS. This article discusses the diverse applications of severity score concept in MS research, and (re)introduces Herbert’s proposal of severity-based MS classification in the context of variability of MS severity.
AB - Severity score represents disease duration–adjusted mean rank of disability in multiple sclerosis (MS) patients from the reference population. This measure allows one to compare the relative rates of disease progression among patients, patient subgroups, and across epochs, which opens up new question of what accounts for the observed differences in severity, and can be used to assess correlation between disease severity and clinical, radiologic, immunologic, genetic, and environmental variables of interest. Severity score can also prove useful for developing prognostic tools in MS. This article discusses the diverse applications of severity score concept in MS research, and (re)introduces Herbert’s proposal of severity-based MS classification in the context of variability of MS severity.
KW - Multiple sclerosis severity
KW - aggressive MS
KW - benign MS
KW - disease classification
KW - prognosis
UR - http://www.scopus.com/inward/record.url?scp=85078133491&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85078133491&partnerID=8YFLogxK
U2 - 10.1177/1352458519880125
DO - 10.1177/1352458519880125
M3 - Article
C2 - 31965877
AN - SCOPUS:85078133491
SN - 1352-4585
VL - 26
SP - 548
EP - 553
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
IS - 5
ER -