Multiple Sclerosis Severity Score: Concept and applications

Ilya Kister, Orhun H. Kantarci

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Severity score represents disease duration–adjusted mean rank of disability in multiple sclerosis (MS) patients from the reference population. This measure allows one to compare the relative rates of disease progression among patients, patient subgroups, and across epochs, which opens up new question of what accounts for the observed differences in severity, and can be used to assess correlation between disease severity and clinical, radiologic, immunologic, genetic, and environmental variables of interest. Severity score can also prove useful for developing prognostic tools in MS. This article discusses the diverse applications of severity score concept in MS research, and (re)introduces Herbert’s proposal of severity-based MS classification in the context of variability of MS severity.

Original languageEnglish (US)
Pages (from-to)548-553
Number of pages6
JournalMultiple Sclerosis Journal
Issue number5
StatePublished - Apr 1 2020


  • Multiple sclerosis severity
  • aggressive MS
  • benign MS
  • disease classification
  • prognosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Multiple Sclerosis Severity Score: Concept and applications'. Together they form a unique fingerprint.

Cite this