Multiple sclerosis: Recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment

Claudia Lucchinetti, Wolfgang Brück, John Noseworthy

Research output: Contribution to journalReview article

111 Scopus citations

Abstract

The cause of multiple sclerosis is generally considered to be entirely T cell mediated. However, recent reports of studies in a variety of animal models of inflammatory demyelinating disease, coupled with detailed pathological analysis and neuroimaging studies of multiple sclerosis patients, indicate that the events involved in the formation of the multiple sclerosis lesion may be more complicated. This complex pathogenesis is reflected in the variable response of multiple sclerosis patients to immunomodulatory therapy.

Original languageEnglish (US)
Pages (from-to)259-269
Number of pages11
JournalCurrent opinion in neurology
Volume14
Issue number3
DOIs
StatePublished - Jun 18 2001

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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