Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls

Jun Chen, Nicholas D Chia, Krishna R Kalari, Janet Z. Yao, Martina Novotna, M. Mateo Paz Soldan, David H. Luckey, Eric V. Marietta, Patricio R. Jeraldo, Xianfeng Chen, Brian G Weinshenker, Moses Rodriguez, Orhun H Kantarci, Heidi Nelson, Joseph A Murray, Ashutosh K. Mangalam

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196 Citations (Scopus)

Abstract

Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of MS. Therefore, this study was designed to investigate whether gut microbiota are altered in MS by comparing the fecal microbiota in relapsing remitting MS (RRMS) (n = 31) patients to that of age-and gender-matched healthy controls (n = 36). Phylotype profiles of the gut microbial populations were generated using hypervariable tag sequencing of the V3-V5 region of the 16S ribosomal RNA gene. Detailed fecal microbiome analyses revealed that MS patients had distinct microbial community profile compared to healthy controls. We observed an increased abundance of Psuedomonas, Mycoplana, Haemophilus, Blautia, and Dorea genera in MS patients, whereas control group showed increased abundance of Parabacteroides, Adlercreutzia and Prevotella genera. Thus our study is consistent with the hypothesis that MS patients have gut microbial dysbiosis and further study is needed to better understand their role in the etiopathogenesis of MS.

Original languageEnglish (US)
Article number28484
JournalScientific Reports
Volume6
DOIs
StatePublished - Jun 27 2016

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Multiple Sclerosis
Microbiota
Dysbiosis
Prevotella
16S Ribosomal RNA
Haemophilus
Relapsing-Remitting Multiple Sclerosis
Gastrointestinal Microbiome
Immune System Diseases
rRNA Genes
Control Groups
Population

ASJC Scopus subject areas

  • General

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Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. / Chen, Jun; Chia, Nicholas D; Kalari, Krishna R; Yao, Janet Z.; Novotna, Martina; Soldan, M. Mateo Paz; Luckey, David H.; Marietta, Eric V.; Jeraldo, Patricio R.; Chen, Xianfeng; Weinshenker, Brian G; Rodriguez, Moses; Kantarci, Orhun H; Nelson, Heidi; Murray, Joseph A; Mangalam, Ashutosh K.

In: Scientific Reports, Vol. 6, 28484, 27.06.2016.

Research output: Contribution to journalArticle

Chen, Jun ; Chia, Nicholas D ; Kalari, Krishna R ; Yao, Janet Z. ; Novotna, Martina ; Soldan, M. Mateo Paz ; Luckey, David H. ; Marietta, Eric V. ; Jeraldo, Patricio R. ; Chen, Xianfeng ; Weinshenker, Brian G ; Rodriguez, Moses ; Kantarci, Orhun H ; Nelson, Heidi ; Murray, Joseph A ; Mangalam, Ashutosh K. / Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. In: Scientific Reports. 2016 ; Vol. 6.
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