TY - JOUR
T1 - Multiple sclerosis
T2 - Histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy
AU - Nesbit, Gary M.
AU - Forbes, Glenn S.
AU - Scheithauer, Bernd W.
AU - Okazaki, Haruo
AU - Rodriguez, Moses
PY - 1991/8
Y1 - 1991/8
N2 - The authors retrospectively reviewed the cases of 40 patients with biopsyor autopsy-proved inflammatory demyelination consistent with multiple sclerosis (MS); each patient underwent magnetic resonance (MR) and/or computed tomographic (CT) imaging. In review of the 32 MR and 30 CT examinations, three predominant radiologic patterns were apparent: (a) relatively small homogeneous lesions with no or minimal diffuse enhancement; (b) hypoattenuating lesions on CT scans and hypointense lesions on short-TR MR images, with a contrast material-enhanced, isoattenuating or isointense ring; and (c) lesions that were more infiltrative and ill defined, with mixed attenuation and signal intensity and scattered enhancement. A common radiologic feature was lack of mass effect or edema in white matter surrounding even large lesions. In all but four patients the lesions were classified as active by using both histologic and clinical criteria. Histologically active lesions had various radiologic appearances; however, in all contrast-enhanced studies they demonstrated some form of enhancement. Inactive lesions were homogeneously hypoattenuating on CT scans, hypointense on short-TR MR images, and hyper-intense on unenhanced, long-TR MR images.
AB - The authors retrospectively reviewed the cases of 40 patients with biopsyor autopsy-proved inflammatory demyelination consistent with multiple sclerosis (MS); each patient underwent magnetic resonance (MR) and/or computed tomographic (CT) imaging. In review of the 32 MR and 30 CT examinations, three predominant radiologic patterns were apparent: (a) relatively small homogeneous lesions with no or minimal diffuse enhancement; (b) hypoattenuating lesions on CT scans and hypointense lesions on short-TR MR images, with a contrast material-enhanced, isoattenuating or isointense ring; and (c) lesions that were more infiltrative and ill defined, with mixed attenuation and signal intensity and scattered enhancement. A common radiologic feature was lack of mass effect or edema in white matter surrounding even large lesions. In all but four patients the lesions were classified as active by using both histologic and clinical criteria. Histologically active lesions had various radiologic appearances; however, in all contrast-enhanced studies they demonstrated some form of enhancement. Inactive lesions were homogeneously hypoattenuating on CT scans, hypointense on short-TR MR images, and hyper-intense on unenhanced, long-TR MR images.
KW - Brain, CT, 10.1211
KW - Brain, MR studies, 10.1214
KW - Gadolinium, 10.1211, 10.1214
KW - Sclerosis, multiple, 10.871
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UR - http://www.scopus.com/inward/citedby.url?scp=0025871038&partnerID=8YFLogxK
U2 - 10.1148/radiology.180.2.2068314
DO - 10.1148/radiology.180.2.2068314
M3 - Article
C2 - 2068314
AN - SCOPUS:0025871038
SN - 0033-8419
VL - 180
SP - 467
EP - 474
JO - Radiology
JF - Radiology
IS - 2
ER -