Multiple sclerosis: Epidemiology, genetics, classification, natural history, and clinical outcome measures

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Abstract

The spectrum of MS is broad, with considerable clinical, pathologic52 and radiologic heterogeneity. This heterogeneity, along with the chronic nature of the disease, makes it more difficult to identify the epidemiologic and genetic factors that contribute to MS susceptibility and course. Despite these obstacles, the precision of MS classification has improved. Genetic contribution to MS risk has been proved, and at least one substantial contributor, the major histocompatibility complex, has been identified. The natural history of MS has been more accurately characterized. Finally, more objective and reliable quantitative measures of the disease are evolving, among the most important of which are the MR imaging techniques that are the subject of this issue.

Original languageEnglish (US)
Pages (from-to)611-623
Number of pages13
JournalNeuroimaging Clinics of North America
Volume10
Issue number4
StatePublished - 2000

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Epidemiologic Factors
Molecular Epidemiology
Major Histocompatibility Complex
Natural History
Multiple Sclerosis
Chronic Disease
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology

Cite this

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abstract = "The spectrum of MS is broad, with considerable clinical, pathologic52 and radiologic heterogeneity. This heterogeneity, along with the chronic nature of the disease, makes it more difficult to identify the epidemiologic and genetic factors that contribute to MS susceptibility and course. Despite these obstacles, the precision of MS classification has improved. Genetic contribution to MS risk has been proved, and at least one substantial contributor, the major histocompatibility complex, has been identified. The natural history of MS has been more accurately characterized. Finally, more objective and reliable quantitative measures of the disease are evolving, among the most important of which are the MR imaging techniques that are the subject of this issue.",
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