Multiple sclerosis: Current pathophysiological concepts

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Multiple sclerosis (MS) is an often disabling disease primarily affecting young adults that exhibits extraordinary clinical, radiological, and pathological heterogeneity. We review the following: (a) known environmental and genetic factors that contribute to MS susceptibility; (b) current knowledge regarding fundamental pathophysiological processes in MS, including immune cell recruitment and entry into the central nervous system (CNS), formation of the plaque, and orchestration of the immune response; (c) descriptive and qualitative distinct pathological patterns in MS and their implications; (d) the evidence supporting the causative role of direct toxins, cell-mediated and humorally mediated immune mechanisms, and the concept of a "primary oligodendrogliopathy" in demyelination and axonal injury; (e) the potential benefits of inflammation; (f) the prospects for remyelination; and (g) therapeutic implications and approaches suggested by putative pathophysiological mechanisms.

Original languageEnglish (US)
Pages (from-to)263-281
Number of pages19
JournalLaboratory Investigation
Volume81
Issue number3
StatePublished - 2001

Fingerprint

Multiple Sclerosis
Demyelinating Diseases
Young Adult
Central Nervous System
Inflammation
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Multiple sclerosis : Current pathophysiological concepts. / Wingerchuk, Dean Marko; Lucchinetti, Claudia F; Noseworthy, John H.

In: Laboratory Investigation, Vol. 81, No. 3, 2001, p. 263-281.

Research output: Contribution to journalArticle

@article{b4728e41f23e417d8b65c46391ce7ab7,
title = "Multiple sclerosis: Current pathophysiological concepts",
abstract = "Multiple sclerosis (MS) is an often disabling disease primarily affecting young adults that exhibits extraordinary clinical, radiological, and pathological heterogeneity. We review the following: (a) known environmental and genetic factors that contribute to MS susceptibility; (b) current knowledge regarding fundamental pathophysiological processes in MS, including immune cell recruitment and entry into the central nervous system (CNS), formation of the plaque, and orchestration of the immune response; (c) descriptive and qualitative distinct pathological patterns in MS and their implications; (d) the evidence supporting the causative role of direct toxins, cell-mediated and humorally mediated immune mechanisms, and the concept of a {"}primary oligodendrogliopathy{"} in demyelination and axonal injury; (e) the potential benefits of inflammation; (f) the prospects for remyelination; and (g) therapeutic implications and approaches suggested by putative pathophysiological mechanisms.",
author = "Wingerchuk, {Dean Marko} and Lucchinetti, {Claudia F} and Noseworthy, {John H.}",
year = "2001",
language = "English (US)",
volume = "81",
pages = "263--281",
journal = "Laboratory Investigation",
issn = "0023-6837",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Multiple sclerosis

T2 - Current pathophysiological concepts

AU - Wingerchuk, Dean Marko

AU - Lucchinetti, Claudia F

AU - Noseworthy, John H.

PY - 2001

Y1 - 2001

N2 - Multiple sclerosis (MS) is an often disabling disease primarily affecting young adults that exhibits extraordinary clinical, radiological, and pathological heterogeneity. We review the following: (a) known environmental and genetic factors that contribute to MS susceptibility; (b) current knowledge regarding fundamental pathophysiological processes in MS, including immune cell recruitment and entry into the central nervous system (CNS), formation of the plaque, and orchestration of the immune response; (c) descriptive and qualitative distinct pathological patterns in MS and their implications; (d) the evidence supporting the causative role of direct toxins, cell-mediated and humorally mediated immune mechanisms, and the concept of a "primary oligodendrogliopathy" in demyelination and axonal injury; (e) the potential benefits of inflammation; (f) the prospects for remyelination; and (g) therapeutic implications and approaches suggested by putative pathophysiological mechanisms.

AB - Multiple sclerosis (MS) is an often disabling disease primarily affecting young adults that exhibits extraordinary clinical, radiological, and pathological heterogeneity. We review the following: (a) known environmental and genetic factors that contribute to MS susceptibility; (b) current knowledge regarding fundamental pathophysiological processes in MS, including immune cell recruitment and entry into the central nervous system (CNS), formation of the plaque, and orchestration of the immune response; (c) descriptive and qualitative distinct pathological patterns in MS and their implications; (d) the evidence supporting the causative role of direct toxins, cell-mediated and humorally mediated immune mechanisms, and the concept of a "primary oligodendrogliopathy" in demyelination and axonal injury; (e) the potential benefits of inflammation; (f) the prospects for remyelination; and (g) therapeutic implications and approaches suggested by putative pathophysiological mechanisms.

UR - http://www.scopus.com/inward/record.url?scp=0035076486&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035076486&partnerID=8YFLogxK

M3 - Article

C2 - 11310820

AN - SCOPUS:0035076486

VL - 81

SP - 263

EP - 281

JO - Laboratory Investigation

JF - Laboratory Investigation

SN - 0023-6837

IS - 3

ER -