Multiple sclerosis: Basic concepts and hypothesis

M. Rodriguez

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Multiple sclerosis, an inflammatory disease of the central nervous system, is characterized by primary destruction of myelin. This review covers recent advances in neuropathology, immunogenetics, neuroimmunology, and neurovirology that have provided insights regarding its pathogenesis. Three hypotheses are discussed: (1) autoimmunity, (2) 'bystander' demyelination, and (3) immune destruction of perisistently infected oligodendrocytes. A paradigm for induction of primary demyelinatin is proposed in which immune cells recognize 'foreign' antigens on the surface of oligodendrocytes in the context of major histocompatibility complex gene products. The final results of this scheme may be 'dying-back gliopathy', the alteration being noted first in the most distal extension of the oligodendrocyte - that is, the myelin sheats.

Original languageEnglish (US)
Pages (from-to)570-576
Number of pages7
JournalMayo Clinic Proceedings
Volume64
Issue number5
StatePublished - 1989
Externally publishedYes

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Oligodendroglia
Multiple Sclerosis
Myelin Sheath
Immunogenetics
Central Nervous System Diseases
Demyelinating Diseases
Surface Antigens
Major Histocompatibility Complex
Autoimmunity
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Multiple sclerosis : Basic concepts and hypothesis. / Rodriguez, M.

In: Mayo Clinic Proceedings, Vol. 64, No. 5, 1989, p. 570-576.

Research output: Contribution to journalArticle

Rodriguez, M 1989, 'Multiple sclerosis: Basic concepts and hypothesis', Mayo Clinic Proceedings, vol. 64, no. 5, pp. 570-576.
Rodriguez, M. / Multiple sclerosis : Basic concepts and hypothesis. In: Mayo Clinic Proceedings. 1989 ; Vol. 64, No. 5. pp. 570-576.
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