Abstract
Multiple sclerosis, an inflammatory disease of the central nervous system, is characterized by primary destruction of myelin. This review covers recent advances in neuropathology, immunogenetics, neuroimmunology, and neurovirology that have provided insights regarding its pathogenesis. Three hypotheses are discussed: (1) autoimmunity, (2) 'bystander' demyelination, and (3) immune destruction of perisistently infected oligodendrocytes. A paradigm for induction of primary demyelinatin is proposed in which immune cells recognize 'foreign' antigens on the surface of oligodendrocytes in the context of major histocompatibility complex gene products. The final results of this scheme may be 'dying-back gliopathy', the alteration being noted first in the most distal extension of the oligodendrocyte - that is, the myelin sheats.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 570-576 |
| Number of pages | 7 |
| Journal | Mayo Clinic Proceedings |
| Volume | 64 |
| Issue number | 5 |
| State | Published - 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Multiple sclerosis : Basic concepts and hypothesis. / Rodriguez, M.
In: Mayo Clinic Proceedings, Vol. 64, No. 5, 1989, p. 570-576.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multiple sclerosis
T2 - Basic concepts and hypothesis
AU - Rodriguez, M.
PY - 1989
Y1 - 1989
N2 - Multiple sclerosis, an inflammatory disease of the central nervous system, is characterized by primary destruction of myelin. This review covers recent advances in neuropathology, immunogenetics, neuroimmunology, and neurovirology that have provided insights regarding its pathogenesis. Three hypotheses are discussed: (1) autoimmunity, (2) 'bystander' demyelination, and (3) immune destruction of perisistently infected oligodendrocytes. A paradigm for induction of primary demyelinatin is proposed in which immune cells recognize 'foreign' antigens on the surface of oligodendrocytes in the context of major histocompatibility complex gene products. The final results of this scheme may be 'dying-back gliopathy', the alteration being noted first in the most distal extension of the oligodendrocyte - that is, the myelin sheats.
AB - Multiple sclerosis, an inflammatory disease of the central nervous system, is characterized by primary destruction of myelin. This review covers recent advances in neuropathology, immunogenetics, neuroimmunology, and neurovirology that have provided insights regarding its pathogenesis. Three hypotheses are discussed: (1) autoimmunity, (2) 'bystander' demyelination, and (3) immune destruction of perisistently infected oligodendrocytes. A paradigm for induction of primary demyelinatin is proposed in which immune cells recognize 'foreign' antigens on the surface of oligodendrocytes in the context of major histocompatibility complex gene products. The final results of this scheme may be 'dying-back gliopathy', the alteration being noted first in the most distal extension of the oligodendrocyte - that is, the myelin sheats.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024354983&partnerID=8YFLogxK
M3 - Article
C2 - 2657238
AN - SCOPUS:0024354983
VL - 64
SP - 570
EP - 576
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 5
ER -