Multiple myeloma involving central nervous system: High frequency of chromosome 17p13.1 (p53) deletions

Hong Chang, Stephen Sloan, Dan Li, A. Keith Stewart

Research output: Contribution to journalArticle

94 Scopus citations

Abstract

Central nervous system (CNS) involvement is an unusual manifestation in multiple myeloma (MM). The molecular basis of CNS myeloma is poorly understood. MM is characterized by translocations involving the immunoglobulin heavy chain (IgH) locus and frequent 13q deletions. Alterations of p53 or c-myc in MM may represent secondary changes associated with disease progression. We investigated nine patients with CNS MM using interphase fluorescence in situ hybridization (FISH) combined with immunofluorescence detection of the cytoplasmic light chain (cIg-FISH) for the presence of above genomic aberrations. Of nine patients studied, eight cases had hemizygous p53 deletion and 4 had 13q deletions. Of the patients with 13q deletions, two had IgH translocations, one involving 4p16.3 (FGFR3), the other involving 16q23 (c-maf). The high incidence of p53 deletions detected by cIg-FISH in CNS myeloma may be a marker for chromosomal instability, and may be associated with metastatic features of myeloma cells.

Original languageEnglish (US)
Pages (from-to)280-284
Number of pages5
JournalBritish journal of haematology
Volume127
Issue number3
DOIs
StatePublished - Nov 2004

Keywords

  • Central nervous system
  • Fluorescence in situ hybridization
  • Myeloma
  • Prognostic factor
  • p53 deletions

ASJC Scopus subject areas

  • Hematology

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