Multiple myeloma: Evolving genetic events and host interactions

W. Michael Kuehl, Peter Leif Bergsagel

Research output: Contribution to journalArticle

628 Citations (Scopus)

Abstract

Multiple myeloma is a neoplasm of terminally differentiated B cells (plasma cells) in which chromosome translocations frequently place oncogenes under the control of immunoglobulin enhancers. Unlike most haematopoietic cancers, multiple myeloma often has complex chromosomal abnormalities that are reminiscent of epithelial tumours. What causes full-blown myeloma? And can our molecular understanding of this common haematological malignancy be used to develop effective preventive and treatment strategies?

Original languageEnglish (US)
Pages (from-to)175-187
Number of pages13
JournalNature Reviews Cancer
Volume2
Issue number3
StatePublished - Mar 2002
Externally publishedYes

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Multiple Myeloma
Neoplasms
Hematologic Neoplasms
Plasma Cells
Oncogenes
Chromosome Aberrations
Immunoglobulins
B-Lymphocytes
Chromosomes

ASJC Scopus subject areas

  • Cancer Research

Cite this

Multiple myeloma : Evolving genetic events and host interactions. / Kuehl, W. Michael; Bergsagel, Peter Leif.

In: Nature Reviews Cancer, Vol. 2, No. 3, 03.2002, p. 175-187.

Research output: Contribution to journalArticle

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