Multiple myeloma: Evolving genetic events and host interactions

W. Michael Kuehl; P. Leif Bergsagel

doi:10.1038/nrc746

Multiple myeloma: Evolving genetic events and host interactions

W. Michael Kuehl, P. Leif Bergsagel

Hematology/Oncology

Research output: Contribution to journal › Review article › peer-review

656 Scopus citations

Abstract

Multiple myeloma is a neoplasm of terminally differentiated B cells (plasma cells) in which chromosome translocations frequently place oncogenes under the control of immunoglobulin enhancers. Unlike most haematopoietic cancers, multiple myeloma often has complex chromosomal abnormalities that are reminiscent of epithelial tumours. What causes full-blown myeloma? And can our molecular understanding of this common haematological malignancy be used to develop effective preventive and treatment strategies?

Original language	English (US)
Pages (from-to)	175-187
Number of pages	13
Journal	Nature Reviews Cancer
Volume	2
Issue number	3
DOIs	https://doi.org/10.1038/nrc746
State	Published - Mar 2002

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/nrc746

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title = "Multiple myeloma: Evolving genetic events and host interactions",

abstract = "Multiple myeloma is a neoplasm of terminally differentiated B cells (plasma cells) in which chromosome translocations frequently place oncogenes under the control of immunoglobulin enhancers. Unlike most haematopoietic cancers, multiple myeloma often has complex chromosomal abnormalities that are reminiscent of epithelial tumours. What causes full-blown myeloma? And can our molecular understanding of this common haematological malignancy be used to develop effective preventive and treatment strategies?",

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Multiple myeloma: Evolving genetic events and host interactions

Abstract

ASJC Scopus subject areas

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