Multiple myeloma: Evolving genetic events and host interactions

W. Michael Kuehl, P. Leif Bergsagel

Research output: Contribution to journalReview articlepeer-review

649 Scopus citations

Abstract

Multiple myeloma is a neoplasm of terminally differentiated B cells (plasma cells) in which chromosome translocations frequently place oncogenes under the control of immunoglobulin enhancers. Unlike most haematopoietic cancers, multiple myeloma often has complex chromosomal abnormalities that are reminiscent of epithelial tumours. What causes full-blown myeloma? And can our molecular understanding of this common haematological malignancy be used to develop effective preventive and treatment strategies?

Original languageEnglish (US)
Pages (from-to)175-187
Number of pages13
JournalNature Reviews Cancer
Volume2
Issue number3
DOIs
StatePublished - Mar 2002

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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