Multiple mutant clones in blood rarely coexist

David M Dingli, Jorge M. Pacheco, Arne Traulsen

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Leukemias arise due to mutations in the genome of hematopoietic (blood) cells. Hematopoiesis has a multicompartment architecture, with cells exhibiting different rates of replication and differentiation. At the root of this process, one finds a small number of stem cells, and hence the description of the mutation-selection dynamics of blood cells calls for a stochastic approach. We use stochastic dynamics to investigate to which extent acquired hematopoietic disorders are associated with mutations of single or multiple genes within developing blood cells. Our analysis considers the appearance of mutations both in the stem cell compartment as well as in more committed compartments. We conclude that in the absence of genomic instability, acquired hematopoietic disorders due to mutations in multiple genes are most likely very rare events, as multiple mutations typically require much longer development times compared to those associated with a single mutation.

Original languageEnglish (US)
Article number021915
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume77
Issue number2
DOIs
StatePublished - Feb 27 2008

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mutations
Clone
Mutant
blood
Blood
Mutation
blood cells
Stem Cells
stem cells
Cell
compartments
genes
Disorder
hematopoiesis
Hematopoiesis
disorders
Gene
leukemias
Rare Events
genome

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Condensed Matter Physics
  • Statistical and Nonlinear Physics
  • Mathematical Physics

Cite this

Multiple mutant clones in blood rarely coexist. / Dingli, David M; Pacheco, Jorge M.; Traulsen, Arne.

In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, Vol. 77, No. 2, 021915, 27.02.2008.

Research output: Contribution to journalArticle

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