Multiple molecular forms of acetylcholinesterase in rat vagus nerve, smooth muscle, and heart

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Extracts of rat tissues were subjected to ultracentrifugation on linear density gradients of sucrose (5-20%) and fractions of these gradients were analyzed for acetylcholinesterase (AChE) activity. Most of the AChE activity in extracts of vagus nerve was found to sediment at 10S. However, 16S AChE, previously thought to be confined to somatic motor nerves and skeletal muscle, was observed to accumulate rapidly at a nerve ligation. A search for this rapidly sedimenting form of AChE was carried out in tissues receiving vagal innervation. Significant amounts of 16S AChE were detected in the heart, especially in the right atrium, and in several regions of the gut. It was concluded that 16S AChE is distributed more widely than has preiously been recognized.

Original languageEnglish (US)
Pages (from-to)1151-1154
Number of pages4
JournalJournal of Neurochemistry
Volume35
Issue number5
StatePublished - 1980

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Vagus Nerve
Acetylcholinesterase
Smooth Muscle
Muscle
Rats
Tissue
Tissue Extracts
Ultracentrifugation
Heart Atria
Ligation
Sucrose
rat Ache protein
Sediments
Skeletal Muscle

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Multiple molecular forms of acetylcholinesterase in rat vagus nerve, smooth muscle, and heart. / Skau, K. A.; Brimijoin, William Stephen.

In: Journal of Neurochemistry, Vol. 35, No. 5, 1980, p. 1151-1154.

Research output: Contribution to journalArticle

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