TY - JOUR
T1 - Multiple meningiomas
T2 - does quantity matter? a population-based survival analysis with underlined age and sex differences
AU - Ramos-Fresnedo, Andres
AU - Domingo, Ricardo A.
AU - Vivas-Buitrago, Tito
AU - Lundy, Larry
AU - Trifiletti, Daniel M.
AU - Jentoft, Mark E.
AU - Desai, Amit B.
AU - Quiñones-Hinojosa, Alfredo
N1 - Funding Information:
AQH was supported by the Mayo Clinic Professorship and a Clinician Investigator Award, and Florida State Department of Health Research Grant, and the Mayo Clinic Graduate School, as well as the NIH (R33CA24018101A1, R43CA221490, R01CA200399, R01CA195503, and R01CA216855).
Funding Information:
SEER collects demographic, clinical, and therapeutic data from 19 different registries from 19 different states within the United States of America (USA) and is funded through the National Cancer Institute, Center of Disease Control, and funds provided by each state [].
Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Introduction: Intracranial meningiomas rarely present with multiple lesions. To the best of our knowledge, current literature regarding meningiomatosis (MM) is mostly comprised of small case series and individual reports. Hence, survival outcome data are limited. The Objective of this study is to explore the influence of sex, age, and number of lesions on overall survival (OS) in patients with MM. Methods: We obtained demographic and clinical data from the surveillance, epidemiology, and end results program (SEER) on adult patients diagnosed with meningiomas from 1975 to 2017. Univariable and multivariable analyses were conducted to assess whether number of lesions, age, and sex had a significant influence on OS. Results: 99,918 cases were included. Results showed that MM patients had a significantly decreased OS when compared to patients with a single lesion (median OS of 94 and 180 months, respectively; p < 0.001). Further analysis showed a progressive decrease on OS for every additional lesion; 2 (HR 1.659 [CI 95% 1.612–1.708], p < 0.001), 3 (HR 1.877 [CI 95% 1.773–1.988], p < 0.001), and ≥ 4 (HR 2.116 [CI 95% 1.886–2.373], p < 0.001). When assessing for sex differences, female patients had increased OS (HR 0.778 [CI 95% 0.743–0.815], p < 0.001) and decreased risk of developing MM (HR 0.809 [CI 95% 0.784–0.835], p < 0.001). Conclusion: Increasing number of meningiomas has a significant negative impact on OS, with a progressive decrease on survival for every additional lesion. Furthermore, female patients had increased OS and decreased risk to develop MM.
AB - Introduction: Intracranial meningiomas rarely present with multiple lesions. To the best of our knowledge, current literature regarding meningiomatosis (MM) is mostly comprised of small case series and individual reports. Hence, survival outcome data are limited. The Objective of this study is to explore the influence of sex, age, and number of lesions on overall survival (OS) in patients with MM. Methods: We obtained demographic and clinical data from the surveillance, epidemiology, and end results program (SEER) on adult patients diagnosed with meningiomas from 1975 to 2017. Univariable and multivariable analyses were conducted to assess whether number of lesions, age, and sex had a significant influence on OS. Results: 99,918 cases were included. Results showed that MM patients had a significantly decreased OS when compared to patients with a single lesion (median OS of 94 and 180 months, respectively; p < 0.001). Further analysis showed a progressive decrease on OS for every additional lesion; 2 (HR 1.659 [CI 95% 1.612–1.708], p < 0.001), 3 (HR 1.877 [CI 95% 1.773–1.988], p < 0.001), and ≥ 4 (HR 2.116 [CI 95% 1.886–2.373], p < 0.001). When assessing for sex differences, female patients had increased OS (HR 0.778 [CI 95% 0.743–0.815], p < 0.001) and decreased risk of developing MM (HR 0.809 [CI 95% 0.784–0.835], p < 0.001). Conclusion: Increasing number of meningiomas has a significant negative impact on OS, with a progressive decrease on survival for every additional lesion. Furthermore, female patients had increased OS and decreased risk to develop MM.
KW - Meningiomatosis
KW - Multiple meningiomas
KW - National database
KW - SEER
KW - Sex
KW - Survival
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U2 - 10.1007/s11060-020-03620-7
DO - 10.1007/s11060-020-03620-7
M3 - Article
C2 - 32986140
AN - SCOPUS:85091686296
VL - 149
SP - 413
EP - 420
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
SN - 0167-594X
IS - 3
ER -