Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development

Gil D. Rabinovici, Maria C. Carrillo, Mark Forman, Susan DeSanti, David S. Miller, Nicholas Kozauer, Ronald Carl Petersen, Christopher Randolph, David S Knopman, Eric E. Smith, Maria Isaac, Niklas Mattsson, Lisa J. Bain, James A. Hendrix, John R. Sims

Research output: Contribution to journalShort survey

26 Citations (Scopus)

Abstract

Dementia is often characterized as being caused by one of several major diseases, such as Alzheimer's disease (AD), cerebrovascular disease, Lewy body disease, or a frontotemporal degeneration. Failure to acknowledge that more than one entity may be present precludes attempts to understand interactive relationships. The clinicopathological studies of dementia demonstrate that multiple pathologic processes often coexist. How overlapping pathologic findings affect the diagnosis and treatment of clinical AD and other dementia phenotypes was the topic taken up by the Alzheimer's Association's Research Roundtable in October 2014. This review will cover the neuropathologic basis of dementia, provide clinical perspectives on multiple pathologies, and discuss therapeutics and biomarkers targeting overlapping pathologies and how these issues impact clinical trials.High prevalence of multiple pathologic findings among individuals with clinical diagnosis of AD suggests that new treatment strategies may be needed to effectively treat AD and other dementing illnesses.

Original languageEnglish (US)
Pages (from-to)83-91
Number of pages9
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Dementia
Alzheimer Disease
Pharmaceutical Preparations
Pathology
Cerebrovascular Disorders
Lewy Body Disease
Pathologic Processes
Biomarkers
Clinical Trials
Phenotype
Neuropathology
Research
Therapeutics

Keywords

  • Alzheimer's disease (AD)
  • Cerebrovascular disease
  • Frontotemporal degeneration
  • Lewy body disease
  • Tau
  • TDP-43
  • α-Synuclein
  • β-amyloid

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development. / Rabinovici, Gil D.; Carrillo, Maria C.; Forman, Mark; DeSanti, Susan; Miller, David S.; Kozauer, Nicholas; Petersen, Ronald Carl; Randolph, Christopher; Knopman, David S; Smith, Eric E.; Isaac, Maria; Mattsson, Niklas; Bain, Lisa J.; Hendrix, James A.; Sims, John R.

In: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Vol. 3, No. 1, 01.01.2017, p. 83-91.

Research output: Contribution to journalShort survey

Rabinovici, GD, Carrillo, MC, Forman, M, DeSanti, S, Miller, DS, Kozauer, N, Petersen, RC, Randolph, C, Knopman, DS, Smith, EE, Isaac, M, Mattsson, N, Bain, LJ, Hendrix, JA & Sims, JR 2017, 'Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 3, no. 1, pp. 83-91. https://doi.org/10.1016/j.trci.2016.09.002
Rabinovici, Gil D. ; Carrillo, Maria C. ; Forman, Mark ; DeSanti, Susan ; Miller, David S. ; Kozauer, Nicholas ; Petersen, Ronald Carl ; Randolph, Christopher ; Knopman, David S ; Smith, Eric E. ; Isaac, Maria ; Mattsson, Niklas ; Bain, Lisa J. ; Hendrix, James A. ; Sims, John R. / Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development. In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2017 ; Vol. 3, No. 1. pp. 83-91.
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