Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development

Gil D. Rabinovici; Maria C. Carrillo; Mark Forman; Susan DeSanti; David S. Miller; Nicholas Kozauer; Ronald C. Petersen; Christopher Randolph; David S. Knopman; Eric E. Smith; Maria Isaac; Niklas Mattsson; Lisa J. Bain; James A. Hendrix; John R. Sims

doi:10.1016/j.trci.2016.09.002

Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development

Gil D. Rabinovici, Maria C. Carrillo, Mark Forman, Susan DeSanti, David S. Miller, Nicholas Kozauer, Ronald C. Petersen, Christopher Randolph, David S. Knopman, Eric E. Smith, Maria Isaac, Niklas Mattsson, Lisa J. Bain, James A. Hendrix, John R. Sims

Research output: Contribution to journal › Short survey › peer-review

45 Scopus citations

Abstract

Dementia is often characterized as being caused by one of several major diseases, such as Alzheimer's disease (AD), cerebrovascular disease, Lewy body disease, or a frontotemporal degeneration. Failure to acknowledge that more than one entity may be present precludes attempts to understand interactive relationships. The clinicopathological studies of dementia demonstrate that multiple pathologic processes often coexist. How overlapping pathologic findings affect the diagnosis and treatment of clinical AD and other dementia phenotypes was the topic taken up by the Alzheimer's Association's Research Roundtable in October 2014. This review will cover the neuropathologic basis of dementia, provide clinical perspectives on multiple pathologies, and discuss therapeutics and biomarkers targeting overlapping pathologies and how these issues impact clinical trials.High prevalence of multiple pathologic findings among individuals with clinical diagnosis of AD suggests that new treatment strategies may be needed to effectively treat AD and other dementing illnesses.

Original language	English (US)
Pages (from-to)	83-91
Number of pages	9
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/j.trci.2016.09.002
State	Published - Jan 1 2017

Keywords

Alzheimer's disease (AD)
Cerebrovascular disease
Frontotemporal degeneration
Lewy body disease
TDP-43
Tau
α-Synuclein
β-amyloid

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1016/j.trci.2016.09.002

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Rabinovici, G. D., Carrillo, M. C., Forman, M., DeSanti, S., Miller, D. S., Kozauer, N., Petersen, R. C., Randolph, C., Knopman, D. S., Smith, E. E., Isaac, M., Mattsson, N., Bain, L. J., Hendrix, J. A., & Sims, J. R. (2017). Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 3(1), 83-91. https://doi.org/10.1016/j.trci.2016.09.002

Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development. / Rabinovici, Gil D.; Carrillo, Maria C.; Forman, Mark et al.
In: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Vol. 3, No. 1, 01.01.2017, p. 83-91.

Research output: Contribution to journal › Short survey › peer-review

Rabinovici, GD, Carrillo, MC, Forman, M, DeSanti, S, Miller, DS, Kozauer, N, Petersen, RC, Randolph, C, Knopman, DS, Smith, EE, Isaac, M, Mattsson, N, Bain, LJ, Hendrix, JA & Sims, JR 2017, 'Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 3, no. 1, pp. 83-91. https://doi.org/10.1016/j.trci.2016.09.002

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Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development

Abstract

Keywords

ASJC Scopus subject areas

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