Multiple B cell malignancies in patients with chronic lymphocytic leukemia: epidemiology, pathology, and clinical implications

Sameer A. Parikh, Philip J. Meacham, Clive S Zent, Andrew G. Evans

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) is associated with increased risk for certain cancers, but relatively little is known about the risk for these patients to develop additional B cell malignancies. Here, we review the available epidemiological data on multiple B cell malignancies in CLL, discuss diagnostic methods and proper pathologic evaluation to distinguish CLL from other B cell malignancies, and address clinical challenges and unmet needs in caring for CLL patients with unrelated B cell malignancies and disease transformation. Considerations include CLL patients with unrelated monoclonal B cell lymphocytosis, biclonal CLL, secondary B cell non-Hodgkin lymphomas, and Richter syndrome–both clonally related transformation and de novo large B cell lymphoma. We address the challenges that remain in order to better understand the underlying risk factors and biology that may put CLL patients at increased risk of developing multiple B cell neoplasia.

Original languageEnglish (US)
Pages (from-to)1037-1051
Number of pages15
JournalLeukemia and Lymphoma
Volume61
Issue number5
DOIs
StatePublished - Apr 15 2020

Keywords

  • CLL
  • DLBCL
  • lymphoid neoplasms
  • secondary malignancies
  • transformation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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