Abstract
Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) is associated with increased risk for certain cancers, but relatively little is known about the risk for these patients to develop additional B cell malignancies. Here, we review the available epidemiological data on multiple B cell malignancies in CLL, discuss diagnostic methods and proper pathologic evaluation to distinguish CLL from other B cell malignancies, and address clinical challenges and unmet needs in caring for CLL patients with unrelated B cell malignancies and disease transformation. Considerations include CLL patients with unrelated monoclonal B cell lymphocytosis, biclonal CLL, secondary B cell non-Hodgkin lymphomas, and Richter syndrome–both clonally related transformation and de novo large B cell lymphoma. We address the challenges that remain in order to better understand the underlying risk factors and biology that may put CLL patients at increased risk of developing multiple B cell neoplasia.
Original language | English (US) |
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Pages (from-to) | 1037-1051 |
Number of pages | 15 |
Journal | Leukemia and Lymphoma |
Volume | 61 |
Issue number | 5 |
DOIs | |
State | Published - Apr 15 2020 |
Keywords
- CLL
- DLBCL
- lymphoid neoplasms
- secondary malignancies
- transformation
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research