Multiple active X chromosomes in myelofibrosis with myeloid metaplasia

Daniel L. Van Dyke, Joseph P. Abraham, Koichi Maeda, Lester Weiss, Mary Poel

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A woman with myelofibrosis and myeloid metaplasia had a karyotype of 47,X,del(X)(q22), +del(X)(q22) in unstimulated peripheral blood and bone marrow aspirate cultures. The normal X chromosome was late replicating, and the two deleted X chromosomes always replicated early and synchronously. The karyotype from phytohemagglutin-stimulated peripheral blood cultures was uniformly 46,XX. Structurally abnormal X chromosomes are exceedingly rare in myeloproliferative disease. The abnormal karyotype very likely reflects monoclonal proliferation of an abnormal myeloid cell line. The X chromosome inactivation process, which acts upon embryonic somatic cells of all mammals, apparently does not react to postembryonic nondisjunction of the active X chromosome.

Original languageEnglish (US)
Pages (from-to)137-144
Number of pages8
JournalCancer Genetics and Cytogenetics
Volume3
Issue number2
DOIs
StatePublished - 1981
Externally publishedYes

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Primary Myelofibrosis
X Chromosome
Karyotype
Abnormal Karyotype
X Chromosome Inactivation
Myeloid Cells
Mammals
Bone Marrow
Cell Line

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Multiple active X chromosomes in myelofibrosis with myeloid metaplasia. / Van Dyke, Daniel L.; Abraham, Joseph P.; Maeda, Koichi; Weiss, Lester; Poel, Mary.

In: Cancer Genetics and Cytogenetics, Vol. 3, No. 2, 1981, p. 137-144.

Research output: Contribution to journalArticle

Van Dyke, Daniel L. ; Abraham, Joseph P. ; Maeda, Koichi ; Weiss, Lester ; Poel, Mary. / Multiple active X chromosomes in myelofibrosis with myeloid metaplasia. In: Cancer Genetics and Cytogenetics. 1981 ; Vol. 3, No. 2. pp. 137-144.
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