Multinucleated giant cells in acquired immunodeficiency syndrome encephalopathy: Origin from endogenous microglia?

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62 Scopus citations

Abstract

Multinucleated giant cells that are characteristic of the encephalomyelopathy of acquired immunodeficiency syndrome are stained by a lectin histochemical method. The particular lectin used, Ricinus communis agglutinin I, has been shown to bind to endogenous microglial cells in human brain, as well as to endothelial cells of blood vessels. These results suggest that multinucleated giant cells in the brain of patients with acquired immunodeficiency syndrome may be derived from endogenous microglia.

Original languageEnglish (US)
Pages (from-to)967-968
Number of pages2
JournalArchives of Pathology and Laboratory Medicine
Volume110
Issue number10
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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