Multinodular/plexiform (multifascicular) schwannomas of major peripheral nerves: An underrecognized part of the spectrum of schwannomas - Clinical article

Marie Noëlle Hébert-Blouin, Kimberly K. Amrami, Bernd W. Scheithauer, Robert J. Spinner

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Object. In clinical practice, schwannomas are among the most common types of nerve sheath tumors. Their clinical presentation, imaging characteristics, and operative features are well known. Over the past 20 years, clinical outcomes have improved due to resection of these tumors at a fascicular level. Despite these advances, a subgroup of patients with schwannomas is associated with a disappointing neurological outcome following resection. The purpose of this study was to correlate the imaging and histological features in this group of patients with more anatomically complex forms of schwannomas. Methods. In a retrospective review performed at their institution over a 10-year period, the authors found a subgroup of patients with complex multinodular/plexiform schwannomas affecting major peripheral nerves. Eleven patients were identified, and the clinical, imaging, and pathological features of their disease were reviewed. Results. The clinical presentation of multinodular/plexiform schwannomas of major peripheral nerves may be similar to that of conventional schwannomas, but their imaging features, operative appearance, and outcomes differ. Conclusions. Preoperatively and intraoperatively, the distinguishing features of multinodular/plexiform schwannomas of major peripheral nerves may be subtle and can easily go unrecognized, thus explaining the often suboptimal surgical results. Familiarity with the imaging and operative features of multinodular/plexiform schwannomas will no doubt alter treatment approaches and improve neurological function in this subgroup of patients.

Original languageEnglish (US)
Pages (from-to)372-382
Number of pages11
JournalJournal of Neurosurgery
Volume112
Issue number2
DOIs
StatePublished - Feb 2010

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Neurilemmoma
Peripheral Nerves
Nerve Sheath Neoplasms

Keywords

  • Clinical outcome
  • Nerve
  • Nerve sheath tumor
  • Plexiform schwannoma
  • Schwannoma
  • Surgical outcome

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Multinodular/plexiform (multifascicular) schwannomas of major peripheral nerves : An underrecognized part of the spectrum of schwannomas - Clinical article. / Hébert-Blouin, Marie Noëlle; Amrami, Kimberly K.; Scheithauer, Bernd W.; Spinner, Robert J.

In: Journal of Neurosurgery, Vol. 112, No. 2, 02.2010, p. 372-382.

Research output: Contribution to journalArticle

Hébert-Blouin, Marie Noëlle ; Amrami, Kimberly K. ; Scheithauer, Bernd W. ; Spinner, Robert J. / Multinodular/plexiform (multifascicular) schwannomas of major peripheral nerves : An underrecognized part of the spectrum of schwannomas - Clinical article. In: Journal of Neurosurgery. 2010 ; Vol. 112, No. 2. pp. 372-382.
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abstract = "Object. In clinical practice, schwannomas are among the most common types of nerve sheath tumors. Their clinical presentation, imaging characteristics, and operative features are well known. Over the past 20 years, clinical outcomes have improved due to resection of these tumors at a fascicular level. Despite these advances, a subgroup of patients with schwannomas is associated with a disappointing neurological outcome following resection. The purpose of this study was to correlate the imaging and histological features in this group of patients with more anatomically complex forms of schwannomas. Methods. In a retrospective review performed at their institution over a 10-year period, the authors found a subgroup of patients with complex multinodular/plexiform schwannomas affecting major peripheral nerves. Eleven patients were identified, and the clinical, imaging, and pathological features of their disease were reviewed. Results. The clinical presentation of multinodular/plexiform schwannomas of major peripheral nerves may be similar to that of conventional schwannomas, but their imaging features, operative appearance, and outcomes differ. Conclusions. Preoperatively and intraoperatively, the distinguishing features of multinodular/plexiform schwannomas of major peripheral nerves may be subtle and can easily go unrecognized, thus explaining the often suboptimal surgical results. Familiarity with the imaging and operative features of multinodular/plexiform schwannomas will no doubt alter treatment approaches and improve neurological function in this subgroup of patients.",
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