Multimodality therapy for gastroesophageal cancers

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Multimodality therapy is the key to the treatment of carcinomas of the gastroesophageal junction. Chemoradiation followed by esophagectomy appears to be the standars therapy at the present time. Selected patients who respond completely to the chemotherapy and radiation are probably the best candidates for esophagectomy. Although extended lymph node dissection is advocated, there are not sufficient data to determine whether the increased morbidity of the procedure is justified by the improvement in outcome for junctional cancers. Early cancers in nonsurgical patients could potentially be treated by endoscopic methods including endoscopic mucosal resection, which permits accurate staging, and photodynamic therapy, which permits treatment of residual premalignant tissue. Palliation of patients with advanced cancers of the gastroesophageal junction is probably best managed with expandable metal stents, although there is some evidence to suggest that thermal methods of palliation may enhance the quality of life in these patients.

Original languageEnglish (US)
Pages (from-to)527-531
Number of pages5
JournalJournal of Gastrointestinal Surgery
Volume6
Issue number4
DOIs
StatePublished - 2002

Fingerprint

Esophagogastric Junction
Esophagectomy
Neoplasms
Photochemotherapy
Therapeutics
Lymph Node Excision
Stents
Hot Temperature
Metals
Quality of Life
Radiation
Morbidity
Carcinoma
Drug Therapy
Endoscopic Mucosal Resection

ASJC Scopus subject areas

  • Surgery

Cite this

Multimodality therapy for gastroesophageal cancers. / Wang, Kenneth Ke Ning.

In: Journal of Gastrointestinal Surgery, Vol. 6, No. 4, 2002, p. 527-531.

Research output: Contribution to journalArticle

@article{3a5320859297484abf658396b003fcab,
title = "Multimodality therapy for gastroesophageal cancers",
abstract = "Multimodality therapy is the key to the treatment of carcinomas of the gastroesophageal junction. Chemoradiation followed by esophagectomy appears to be the standars therapy at the present time. Selected patients who respond completely to the chemotherapy and radiation are probably the best candidates for esophagectomy. Although extended lymph node dissection is advocated, there are not sufficient data to determine whether the increased morbidity of the procedure is justified by the improvement in outcome for junctional cancers. Early cancers in nonsurgical patients could potentially be treated by endoscopic methods including endoscopic mucosal resection, which permits accurate staging, and photodynamic therapy, which permits treatment of residual premalignant tissue. Palliation of patients with advanced cancers of the gastroesophageal junction is probably best managed with expandable metal stents, although there is some evidence to suggest that thermal methods of palliation may enhance the quality of life in these patients.",
author = "Wang, {Kenneth Ke Ning}",
year = "2002",
doi = "10.1016/S1091-255X(02)00027-6",
language = "English (US)",
volume = "6",
pages = "527--531",
journal = "Journal of Gastrointestinal Surgery",
issn = "1091-255X",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Multimodality therapy for gastroesophageal cancers

AU - Wang, Kenneth Ke Ning

PY - 2002

Y1 - 2002

N2 - Multimodality therapy is the key to the treatment of carcinomas of the gastroesophageal junction. Chemoradiation followed by esophagectomy appears to be the standars therapy at the present time. Selected patients who respond completely to the chemotherapy and radiation are probably the best candidates for esophagectomy. Although extended lymph node dissection is advocated, there are not sufficient data to determine whether the increased morbidity of the procedure is justified by the improvement in outcome for junctional cancers. Early cancers in nonsurgical patients could potentially be treated by endoscopic methods including endoscopic mucosal resection, which permits accurate staging, and photodynamic therapy, which permits treatment of residual premalignant tissue. Palliation of patients with advanced cancers of the gastroesophageal junction is probably best managed with expandable metal stents, although there is some evidence to suggest that thermal methods of palliation may enhance the quality of life in these patients.

AB - Multimodality therapy is the key to the treatment of carcinomas of the gastroesophageal junction. Chemoradiation followed by esophagectomy appears to be the standars therapy at the present time. Selected patients who respond completely to the chemotherapy and radiation are probably the best candidates for esophagectomy. Although extended lymph node dissection is advocated, there are not sufficient data to determine whether the increased morbidity of the procedure is justified by the improvement in outcome for junctional cancers. Early cancers in nonsurgical patients could potentially be treated by endoscopic methods including endoscopic mucosal resection, which permits accurate staging, and photodynamic therapy, which permits treatment of residual premalignant tissue. Palliation of patients with advanced cancers of the gastroesophageal junction is probably best managed with expandable metal stents, although there is some evidence to suggest that thermal methods of palliation may enhance the quality of life in these patients.

UR - http://www.scopus.com/inward/record.url?scp=1842859697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842859697&partnerID=8YFLogxK

U2 - 10.1016/S1091-255X(02)00027-6

DO - 10.1016/S1091-255X(02)00027-6

M3 - Article

C2 - 12127117

AN - SCOPUS:1842859697

VL - 6

SP - 527

EP - 531

JO - Journal of Gastrointestinal Surgery

JF - Journal of Gastrointestinal Surgery

SN - 1091-255X

IS - 4

ER -