Multimodality imaging for epilepsy diagnosis and surgical focus localization: Three-dimensional image correlation and dual isotope SPECT

Benjamin Brinkmann, Richard A. Robb, Terence J. O’Brien, Michael K. O’Connor, Brian P. Mullan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Peri-ictal SPECT is a potentially powerful tool to study changes in regional cerebral blood flow during a partial seizure and to localize the seizure focus for pre-surgical evaluation. Recently we have developed and validated a method for co-registering and normalizing 3D interictal SPECT images to 3D ictal SPECT images and deriving a difference image co-registered to the patient's 3D MRI. This method has been shown to significantly improve clinical outcomes in surgery patients. In order to improve the method's sensitivity and specificity a number of enhancements have been added to the basic technique, including using voxel-based registration to better alignictal and interictal images, dual isotope (Tc-99m and 1-123) SPECT for effective tissue discrimination, and a custom software interface written to facilitate the entire process. We report results that show significant improvement over the original method, and we discuss future work which should continue to improve the method as a clinical tool.

Original languageEnglish (US)
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
PublisherSpringer Verlag
Pages1087-1098
Number of pages12
Volume1496
ISBN (Print)3540651365, 9783540651369
StatePublished - 1998
Event1st International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 1998 - Cambridge, United States
Duration: Oct 11 1998Oct 13 1998

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume1496
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other1st International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 1998
CountryUnited States
CityCambridge
Period10/11/9810/13/98

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ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

Cite this

Brinkmann, B., Robb, R. A., O’Brien, T. J., O’Connor, M. K., & Mullan, B. P. (1998). Multimodality imaging for epilepsy diagnosis and surgical focus localization: Three-dimensional image correlation and dual isotope SPECT. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 1496, pp. 1087-1098). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 1496). Springer Verlag.