Multimodality imaging characteristics of dementia with Lewy bodies

Kejal Kantarci, Val J. Lowe, Bradley F. Boeve, Stephen D. Weigand, Matthew L. Senjem, Scott A. Przybelski, Dennis W. Dickson, Joseph E. Parisi, David S. Knopman, Glenn E. Smith, Tanis J. Ferman, Ronald C. Petersen, Clifford R. Jack

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia after Alzheimer's disease (AD). Our objective was to determine whether the 11C-Pittsburgh Compound-B (PiB) retention and regional hypometabolism on positron emission tomography (PET) and regional cortical atrophy on magnetic resonance imaging (MRI) are complementary in characterizing patients with DLB and differentiating them from AD. We studied age-, gender-, and education-matched patients with a clinical diagnosis of DLB (n = 21), AD (n = 21), and cognitively normal subjects (n = 42). Hippocampal atrophy, global cortical PiB retention and occipital lobe metabolism in combination distinguished DLB from AD better than any of the measurements alone (area under the receiver operating characteristic = 0.98). Five of the DLB and AD patients who underwent autopsy were distinguished through multimodality imaging. These data demonstrate that magnetic resonance imaging and PiB positron emission tomography contribute to characterizing the distinct pathological mechanisms in patients with AD compared with DLB. Occipital and posterior parietotemporal lobe hypometabolism is a distinguishing feature of DLB and this regional hypometabolic pattern is independent of the amyloid pathology.

Original languageEnglish (US)
Pages (from-to)2091-2105
Number of pages15
JournalNeurobiology of aging
Volume33
Issue number9
DOIs
StatePublished - Sep 1 2012

Keywords

  • Alzheimer's disease
  • Dementia with Lewy bodies
  • FDG
  • MRI
  • PET
  • PiB

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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