Multifocal recurrent lung opacities in a renal failure patient

Prasad M. Panse, Eric A. Jensen, Kristopher W. Cummings, Clinton E. Jokerst, Robert W. Viggiano, Maxwell L. Smith, Michael Gotway

Research output: Contribution to journalArticle

Abstract

Pulmonary vasculitides include a broad variety of disorders having in common inflammation and destruction of the blood vessels within the lung. Granulomatosis with polyangiitis (GPA), formerly known as Wegener granulomatosis, is an antineutrophil cytoplasmic antibody (ANCA)-Associated small-vessel vasculitis that affects a number of organ systems, and is the most common of the ANCAassociated vasculitides. GPA affects a broad age range, most commonly presenting in middle-Aged adults. The classic triad of GPA, the combination of upper-Airway disease (sinusitis, otitis media, ulcerations, tracheobronchial stenoses), lower-respiratory tract disease, and glomerulonephritis, is not always evident at presentation. Imaging manifestations of GPA commonly include multiple, bilateral nodules or masses that often show cavitation or necrosis. Less commonly, diffuse lung opacity resulting from alveolar hemorrhage, or tracheobronchial stenoses, may be seen. The diagnosis of systemic GPA can often be suggested when c-ANCA/anti-PR-3 antibodies are detected in the proper clinical context, but not infrequently, the diagnosis rests on recognition of a combination of characteristic clinical, laboratory, and imaging findings in combination with histopathologic material from a biopsy. The mainstay of treatment of GPA is corticosteroid therapy in combination with other immunosuppressive agents.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalClinical Pulmonary Medicine
Volume23
Issue number5
DOIs
StatePublished - 2016

Fingerprint

Granulomatosis with Polyangiitis
Renal Insufficiency
Lung
Vasculitis
Antineutrophil Cytoplasmic Antibodies
Pathologic Constriction
Respiratory Tract Diseases
Sinusitis
Otitis Media
Immunosuppressive Agents
Glomerulonephritis
Blood Vessels
Adrenal Cortex Hormones
Necrosis
Hemorrhage
Inflammation
Biopsy
Antibodies
Therapeutics

Keywords

  • Granulomatosis with polyangiitis
  • Hemorrhage
  • Hemosiderosis
  • Renal failure
  • Vasculitis
  • Wegener

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Panse, P. M., Jensen, E. A., Cummings, K. W., Jokerst, C. E., Viggiano, R. W., Smith, M. L., & Gotway, M. (2016). Multifocal recurrent lung opacities in a renal failure patient. Clinical Pulmonary Medicine, 23(5), 231-236. https://doi.org/10.1097/CPM.0000000000000175

Multifocal recurrent lung opacities in a renal failure patient. / Panse, Prasad M.; Jensen, Eric A.; Cummings, Kristopher W.; Jokerst, Clinton E.; Viggiano, Robert W.; Smith, Maxwell L.; Gotway, Michael.

In: Clinical Pulmonary Medicine, Vol. 23, No. 5, 2016, p. 231-236.

Research output: Contribution to journalArticle

Panse, PM, Jensen, EA, Cummings, KW, Jokerst, CE, Viggiano, RW, Smith, ML & Gotway, M 2016, 'Multifocal recurrent lung opacities in a renal failure patient', Clinical Pulmonary Medicine, vol. 23, no. 5, pp. 231-236. https://doi.org/10.1097/CPM.0000000000000175
Panse PM, Jensen EA, Cummings KW, Jokerst CE, Viggiano RW, Smith ML et al. Multifocal recurrent lung opacities in a renal failure patient. Clinical Pulmonary Medicine. 2016;23(5):231-236. https://doi.org/10.1097/CPM.0000000000000175
Panse, Prasad M. ; Jensen, Eric A. ; Cummings, Kristopher W. ; Jokerst, Clinton E. ; Viggiano, Robert W. ; Smith, Maxwell L. ; Gotway, Michael. / Multifocal recurrent lung opacities in a renal failure patient. In: Clinical Pulmonary Medicine. 2016 ; Vol. 23, No. 5. pp. 231-236.
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