TY - JOUR
T1 - Multifocal inflammatory leukoencephalopathy associated with levamisole therapy
AU - Kimmel, David W.
AU - Wijdicks, Eelco F.M.
AU - Rodriguez, Moses
PY - 1995/2
Y1 - 1995/2
N2 - cerebral demyelinating disease developed in a patient during adjuvant therapy with levamisole for malignant melanoma. This patient had no evidence of previous neurologic disease. Levamisole was administered for 5 weeks (total dose, 1,500 mg). Over a period of 3 weeks, the patient became progressively confused and ataxic. MRI with gadolinium enhancement demonstrated prominent multifocal enhancing white matter lesions. CSF examination revealed an inflammatory profile. After discontinuation of treatment with levamisole and a short course of corticosteroid therapy, the patient's condition dramatically improved. MRI also indicated improvement. Observations in our patient suggest that the leukoencephalopathy that developed in previously reported patients who received 5–fluorouracil and levamisole may have been caused at least partly by levamisole.
AB - cerebral demyelinating disease developed in a patient during adjuvant therapy with levamisole for malignant melanoma. This patient had no evidence of previous neurologic disease. Levamisole was administered for 5 weeks (total dose, 1,500 mg). Over a period of 3 weeks, the patient became progressively confused and ataxic. MRI with gadolinium enhancement demonstrated prominent multifocal enhancing white matter lesions. CSF examination revealed an inflammatory profile. After discontinuation of treatment with levamisole and a short course of corticosteroid therapy, the patient's condition dramatically improved. MRI also indicated improvement. Observations in our patient suggest that the leukoencephalopathy that developed in previously reported patients who received 5–fluorouracil and levamisole may have been caused at least partly by levamisole.
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U2 - 10.1212/wnl.45.2.374
DO - 10.1212/wnl.45.2.374
M3 - Article
C2 - 7854541
AN - SCOPUS:0028869775
SN - 0028-3878
VL - 45
SP - 374
EP - 376
JO - Neurology
JF - Neurology
IS - 2
ER -