Multidisciplinary management and emerging therapeutic strategies in aneurysmal subarachnoid haemorrhage

Alejandro Rabinstein, Giuseppe Lanzino, Eelco FM Wijdicks

Research output: Contribution to journalReview article

108 Citations (Scopus)

Abstract

The management of patients with aneurysmal subarachnoid haemorrhage demands expertise to anticipate, recognise, and promptly treat the many neurological and systemic complications. For this reason, these patients are best cared for in high-volume medical centres with multidisciplinary teams and should preferably be treated in a specialised intensive care unit. Endovascular occlusion and surgical clipping provide complementary alternatives for the treatment of aneurysms. Perfusion scans are redefining the way we detect delayed ischaemia as a growing body of evidence indicates that monitoring vessel diameter is insufficient to prevent cerebral infarctions. Statins, endothelin antagonists, and magnesium sulfate infusion are among the novel strategies being tested for neuroprotection and attenuation of vasospasm. The effectiveness of these treatments is supported by strong experimental data and they represent a new generation of therapeutic options developed from the understanding that vasospasm is primarily caused by endothelial dysfunction.

Original languageEnglish (US)
Pages (from-to)504-519
Number of pages16
JournalThe Lancet Neurology
Volume9
Issue number5
DOIs
StatePublished - May 2010

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Subarachnoid Hemorrhage
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Magnesium Sulfate
Cerebral Infarction
Aneurysm
Intensive Care Units
Ischemia
Perfusion
Therapeutics
Neuroprotection
Endothelin Receptor Antagonists

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Multidisciplinary management and emerging therapeutic strategies in aneurysmal subarachnoid haemorrhage. / Rabinstein, Alejandro; Lanzino, Giuseppe; Wijdicks, Eelco FM.

In: The Lancet Neurology, Vol. 9, No. 5, 05.2010, p. 504-519.

Research output: Contribution to journalReview article

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