Multidipole analysis of simulated epileptic spikes with real background activity

J. M. Stephen, C. J. Aine, D. Ranken, D. Hudson, Jerry J. Shih

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

This simulated magnetoencephalographic study was designed to determine the variability in source parameters with real subject background activity when applying multidipole spatial-temporal dipole analyses, for which the correct model was compared with undermodeled and overmodeled cases. The simulated sources were created from patches of the cortical surface of each subject's MRI. One- and two-source frontal lobe spikes were generated in two cortical regions seen commonly in frontal lobe epilepsy patients tested at our site (orbital frontal and premotor cortex). In general, the modeling results were adequate for the correct model order and the correct model order plus one. In addition, if the localization error was less than 10 mm from the simulated source, the peak latency of the spike and orientation were very reliable, but the peak amplitude was not. The additional source in the overmodeled condition, on the other hand, was not localized reliably across the different epochs within subjects. The results suggest that consistency of the spike localization and inconsistency of other sources will allow one to determine reliably the appropriate model order in real data, and therefore determine single and multifocal spike generators.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalJournal of Clinical Neurophysiology
Volume20
Issue number1
DOIs
StatePublished - 2003
Externally publishedYes

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Frontal Lobe
Frontal Lobe Epilepsy
Spatio-Temporal Analysis
Motor Cortex
Prefrontal Cortex

Keywords

  • Background activity
  • Frontal lobe epilepsy
  • Localization error
  • Magnetoencephalography
  • Multidipole modeling
  • Simulations

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology
  • Neuroscience(all)

Cite this

Multidipole analysis of simulated epileptic spikes with real background activity. / Stephen, J. M.; Aine, C. J.; Ranken, D.; Hudson, D.; Shih, Jerry J.

In: Journal of Clinical Neurophysiology, Vol. 20, No. 1, 2003, p. 1-16.

Research output: Contribution to journalArticle

Stephen, J. M. ; Aine, C. J. ; Ranken, D. ; Hudson, D. ; Shih, Jerry J. / Multidipole analysis of simulated epileptic spikes with real background activity. In: Journal of Clinical Neurophysiology. 2003 ; Vol. 20, No. 1. pp. 1-16.
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