Multicenter phase II study of fludarabine phosphate for patients with newly diagnosed lymphoplasmacytoid lymphoma, Waldenstrom's macroglobulinemia, and mantle-cell lymphoma

James M. Foran, Ama Z.S. Rohatiner, Bertrand Coiffier, Tiziano Barbui, Stephen A. Johnson, Wolfgang Hiddemann, John A. Radford, Andrew J. Norton, Susan M. Tollerfield, Martin P. Wilson, T. Andrew Lister

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146 Scopus citations

Abstract

Purpose: Fludarabine phosphate (F-AMP) has significant activity in follicular lymphoma and in B-cell chronic lymphatic leukemia, where it has demonstrated high complete response (CR) rates. Lymphoplasmacytoid (LPC) lymphoma, Waldenstrom's macroglobulinemia (WM), and mantle-cell lymphoma (MCL) also present with advanced-stage disease and are incurable with standard alkylator-based chemotherapy. A phase II trial was undertaken to determine the activity of F-AMP in patients newly diagnosed with these diseases. Patients and Methods: Between 1992 and 1996, 78 patients (aged 18 to 75 years) received intravenous F-AMP (25 mg/m2/d for 5 days, every 4 weeks) until maximum response, plus two further cycles as consolidation. The primary end point was response rate; secondary end points included time to progression (TTP), duration of response, and overall survival (OS). Results: Forty-four (62%) of 71 assessable patients had a response to F-AMP (LPC lymphoma, 63%; WM, 79%; MCL, 41%); the CR rate was 15%. At a median follow- up of 1.5 years, 19 of 44 responding patients have had progression of lymphoma; the median duration of response was 2.5 years. The median survival has not yet been reached. There was no significant difference in the duration of response or OS between patients with different histologies; TTP was shorter in patients with MCL (P = .015). Myelosuppression was relatively common, and the treatment-related mortality (TRM) was 5%, mostly associated with pancytopenia end infection. Conclusion: Single-agent fludarabine phosphate is active in previously untreated LPC lymphoma and WM, with only moderate activity in MCL. However, the CR rate is low, and the TRM is relatively high. Its role in combination chemotherapy remains to be demonstrated.

Original languageEnglish (US)
Pages (from-to)546-553
Number of pages8
JournalJournal of Clinical Oncology
Volume17
Issue number2
DOIs
StatePublished - Feb 1999

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Foran, J. M., Rohatiner, A. Z. S., Coiffier, B., Barbui, T., Johnson, S. A., Hiddemann, W., Radford, J. A., Norton, A. J., Tollerfield, S. M., Wilson, M. P., & Lister, T. A. (1999). Multicenter phase II study of fludarabine phosphate for patients with newly diagnosed lymphoplasmacytoid lymphoma, Waldenstrom's macroglobulinemia, and mantle-cell lymphoma. Journal of Clinical Oncology, 17(2), 546-553. https://doi.org/10.1200/jco.1999.17.2.546