Multicenter linkage study of schizophrenia loci on chromosome 22q

B. J. Mowry, P. A. Holmans, A. E. Pulver, P. V. Gejman, B. Riley, N. M. Williams, C. Laurent, S. G. Schwab, D. B. Wildenauer, S. Bauché, M. J. Owen, B. Wormley, A. R. Sanders, G. Nestadt, K. Y. Liang, J. Duan, R. Ribble, N. Norton, S. Soubigou, W. MaierK. R. Ewen-White, N. DeMarchi, B. Carpenter, D. Walsh, H. Williams, M. Jay, M. Albus, D. A. Nertney, G. Papadimitriou, A. O'Neill, M. C. O'Donovan, J. F. Deleuze, F. B. Lerer, D. Dikeos, K. S. Kendler, J. Mallet, J. M. Silverman, R. R. Crowe, D. F. Levinson

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of 779 pedigrees. We also incorporated age at onset and sex into the analysis as covariates. No significant evidence for linkage to schizophrenia or for linkage associated with earlier age at onset, gender, or heterogeneity across sites was observed. We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkage analysis even in large samples.

Original languageEnglish (US)
Pages (from-to)784-795
Number of pages12
JournalMolecular Psychiatry
Volume9
Issue number8
DOIs
StatePublished - Aug 1 2004

Keywords

  • Chromosomes, human, pair 22
  • Genetics, medical
  • Genetics, molecular
  • Linkage (genetics)
  • Schizophrenia

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Multicenter linkage study of schizophrenia loci on chromosome 22q'. Together they form a unique fingerprint.

  • Cite this

    Mowry, B. J., Holmans, P. A., Pulver, A. E., Gejman, P. V., Riley, B., Williams, N. M., Laurent, C., Schwab, S. G., Wildenauer, D. B., Bauché, S., Owen, M. J., Wormley, B., Sanders, A. R., Nestadt, G., Liang, K. Y., Duan, J., Ribble, R., Norton, N., Soubigou, S., ... Levinson, D. F. (2004). Multicenter linkage study of schizophrenia loci on chromosome 22q. Molecular Psychiatry, 9(8), 784-795. https://doi.org/10.1038/sj.mp.4001481