Multicenter investigation of coronary stenting to treat acute or threatened closure after percutaneous transluminal coronary angioplasty: Clinical and angiographic outcomes

Barry S. George, Gary S. Roubin, Neal E. Fearnot, Cass A. Pinkerton, Albert E. Raizner, Spencer B. King, David Holmes, Eric J. Topol, Dean J. Kereiakes, Geoffrey O. Hartzler, William D. Voorhees

Research output: Contribution to journalArticle

342 Citations (Scopus)

Abstract

Objectives. This study reports on the initial experience with the Gianturco-Roubin flexible coronary stent. The immediate and 6-month efficacy of the device and the incidence of the complications of death, myocardial infarction, emergency coronary artery bypass surgery and recurrent ischemic events are presented. Background. Abrupt or threatened vessel closure after coronary angioplasty is associated with increased risk of myocardial infarction, emergency coronary artery bypass graft surgery and in-hospital death. When dissection or prolapse of dilated plaque into the lumen is unresponsive to additional or prolonged balloon catheter inflation, coronary stenting offers a nonsurgical mechanical means to rapidly restore stable vessel geometry and adequate coronary blood flow. Methods. From September 1988 through June 1991, 518 patients underwent attempted coronary stenting with the 20-mm long Gianturco-Roubin coronary stent for acute or threatened vessel closure after angioplasty. In 494 patients, one or more stents were deployed. Thirty-two percent of patients received stents for acute closure and 69% for threatened closure. Results. Successful deployment was achieved in 95.4% of patients. Overall, stenting resulted in an immediate angiographic improvement in the diameter stenosis from 63 ± 25% before stenting to 15 ± 14% after stenting. Emergency coronary artery bypass graft surgery was required in 4.3% (21 of 493 patients). The incidence of in-hospital myocardial infarction (Q wave and non-Q wave) was 5.5% (27 of 493 patients). At 6 months, myocardial infarction was infrequent, occurring in 1.6% (8 of 493 patients). The incidence of in-hospital death was 2.2% (11 of 493 patients). Late death occurred in 7 patients (1.4%) and 34 patients (6.9%) required later bypass graft surgery. Complications included blood loss, primarily from the access site, and subacute thrombosis of the stented vessel in 43 patients (8.7%). Conclusions. The early multicenter experience suggests that this stent is a useful adjunct to coronary angioplasty to prevent or minimize complications associated with flow-limiting coronary artery dissections previously correctable only by surgery. Although this study was not randomized, it demonstrated a high technical success rate and encouraging results with respect to the low incidence of emergency coronary artery bypass graft surgery and myocardial infarction.

Original languageEnglish (US)
Pages (from-to)135-143
Number of pages9
JournalJournal of the American College of Cardiology
Volume22
Issue number1
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

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Coronary Balloon Angioplasty
Stents
Coronary Artery Bypass
Myocardial Infarction
Emergencies
Angioplasty
Transplants
Incidence
Dissection
Prolapse
Economic Inflation
Coronary Vessels
Pathologic Constriction
Thrombosis
Catheters

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Multicenter investigation of coronary stenting to treat acute or threatened closure after percutaneous transluminal coronary angioplasty : Clinical and angiographic outcomes. / George, Barry S.; Roubin, Gary S.; Fearnot, Neal E.; Pinkerton, Cass A.; Raizner, Albert E.; King, Spencer B.; Holmes, David; Topol, Eric J.; Kereiakes, Dean J.; Hartzler, Geoffrey O.; Voorhees, William D.

In: Journal of the American College of Cardiology, Vol. 22, No. 1, 01.01.1993, p. 135-143.

Research output: Contribution to journalArticle

George, Barry S. ; Roubin, Gary S. ; Fearnot, Neal E. ; Pinkerton, Cass A. ; Raizner, Albert E. ; King, Spencer B. ; Holmes, David ; Topol, Eric J. ; Kereiakes, Dean J. ; Hartzler, Geoffrey O. ; Voorhees, William D. / Multicenter investigation of coronary stenting to treat acute or threatened closure after percutaneous transluminal coronary angioplasty : Clinical and angiographic outcomes. In: Journal of the American College of Cardiology. 1993 ; Vol. 22, No. 1. pp. 135-143.
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abstract = "Objectives. This study reports on the initial experience with the Gianturco-Roubin flexible coronary stent. The immediate and 6-month efficacy of the device and the incidence of the complications of death, myocardial infarction, emergency coronary artery bypass surgery and recurrent ischemic events are presented. Background. Abrupt or threatened vessel closure after coronary angioplasty is associated with increased risk of myocardial infarction, emergency coronary artery bypass graft surgery and in-hospital death. When dissection or prolapse of dilated plaque into the lumen is unresponsive to additional or prolonged balloon catheter inflation, coronary stenting offers a nonsurgical mechanical means to rapidly restore stable vessel geometry and adequate coronary blood flow. Methods. From September 1988 through June 1991, 518 patients underwent attempted coronary stenting with the 20-mm long Gianturco-Roubin coronary stent for acute or threatened vessel closure after angioplasty. In 494 patients, one or more stents were deployed. Thirty-two percent of patients received stents for acute closure and 69{\%} for threatened closure. Results. Successful deployment was achieved in 95.4{\%} of patients. Overall, stenting resulted in an immediate angiographic improvement in the diameter stenosis from 63 ± 25{\%} before stenting to 15 ± 14{\%} after stenting. Emergency coronary artery bypass graft surgery was required in 4.3{\%} (21 of 493 patients). The incidence of in-hospital myocardial infarction (Q wave and non-Q wave) was 5.5{\%} (27 of 493 patients). At 6 months, myocardial infarction was infrequent, occurring in 1.6{\%} (8 of 493 patients). The incidence of in-hospital death was 2.2{\%} (11 of 493 patients). Late death occurred in 7 patients (1.4{\%}) and 34 patients (6.9{\%}) required later bypass graft surgery. Complications included blood loss, primarily from the access site, and subacute thrombosis of the stented vessel in 43 patients (8.7{\%}). Conclusions. The early multicenter experience suggests that this stent is a useful adjunct to coronary angioplasty to prevent or minimize complications associated with flow-limiting coronary artery dissections previously correctable only by surgery. Although this study was not randomized, it demonstrated a high technical success rate and encouraging results with respect to the low incidence of emergency coronary artery bypass graft surgery and myocardial infarction.",
author = "George, {Barry S.} and Roubin, {Gary S.} and Fearnot, {Neal E.} and Pinkerton, {Cass A.} and Raizner, {Albert E.} and King, {Spencer B.} and David Holmes and Topol, {Eric J.} and Kereiakes, {Dean J.} and Hartzler, {Geoffrey O.} and Voorhees, {William D.}",
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T1 - Multicenter investigation of coronary stenting to treat acute or threatened closure after percutaneous transluminal coronary angioplasty

T2 - Clinical and angiographic outcomes

AU - George, Barry S.

AU - Roubin, Gary S.

AU - Fearnot, Neal E.

AU - Pinkerton, Cass A.

AU - Raizner, Albert E.

AU - King, Spencer B.

AU - Holmes, David

AU - Topol, Eric J.

AU - Kereiakes, Dean J.

AU - Hartzler, Geoffrey O.

AU - Voorhees, William D.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Objectives. This study reports on the initial experience with the Gianturco-Roubin flexible coronary stent. The immediate and 6-month efficacy of the device and the incidence of the complications of death, myocardial infarction, emergency coronary artery bypass surgery and recurrent ischemic events are presented. Background. Abrupt or threatened vessel closure after coronary angioplasty is associated with increased risk of myocardial infarction, emergency coronary artery bypass graft surgery and in-hospital death. When dissection or prolapse of dilated plaque into the lumen is unresponsive to additional or prolonged balloon catheter inflation, coronary stenting offers a nonsurgical mechanical means to rapidly restore stable vessel geometry and adequate coronary blood flow. Methods. From September 1988 through June 1991, 518 patients underwent attempted coronary stenting with the 20-mm long Gianturco-Roubin coronary stent for acute or threatened vessel closure after angioplasty. In 494 patients, one or more stents were deployed. Thirty-two percent of patients received stents for acute closure and 69% for threatened closure. Results. Successful deployment was achieved in 95.4% of patients. Overall, stenting resulted in an immediate angiographic improvement in the diameter stenosis from 63 ± 25% before stenting to 15 ± 14% after stenting. Emergency coronary artery bypass graft surgery was required in 4.3% (21 of 493 patients). The incidence of in-hospital myocardial infarction (Q wave and non-Q wave) was 5.5% (27 of 493 patients). At 6 months, myocardial infarction was infrequent, occurring in 1.6% (8 of 493 patients). The incidence of in-hospital death was 2.2% (11 of 493 patients). Late death occurred in 7 patients (1.4%) and 34 patients (6.9%) required later bypass graft surgery. Complications included blood loss, primarily from the access site, and subacute thrombosis of the stented vessel in 43 patients (8.7%). Conclusions. The early multicenter experience suggests that this stent is a useful adjunct to coronary angioplasty to prevent or minimize complications associated with flow-limiting coronary artery dissections previously correctable only by surgery. Although this study was not randomized, it demonstrated a high technical success rate and encouraging results with respect to the low incidence of emergency coronary artery bypass graft surgery and myocardial infarction.

AB - Objectives. This study reports on the initial experience with the Gianturco-Roubin flexible coronary stent. The immediate and 6-month efficacy of the device and the incidence of the complications of death, myocardial infarction, emergency coronary artery bypass surgery and recurrent ischemic events are presented. Background. Abrupt or threatened vessel closure after coronary angioplasty is associated with increased risk of myocardial infarction, emergency coronary artery bypass graft surgery and in-hospital death. When dissection or prolapse of dilated plaque into the lumen is unresponsive to additional or prolonged balloon catheter inflation, coronary stenting offers a nonsurgical mechanical means to rapidly restore stable vessel geometry and adequate coronary blood flow. Methods. From September 1988 through June 1991, 518 patients underwent attempted coronary stenting with the 20-mm long Gianturco-Roubin coronary stent for acute or threatened vessel closure after angioplasty. In 494 patients, one or more stents were deployed. Thirty-two percent of patients received stents for acute closure and 69% for threatened closure. Results. Successful deployment was achieved in 95.4% of patients. Overall, stenting resulted in an immediate angiographic improvement in the diameter stenosis from 63 ± 25% before stenting to 15 ± 14% after stenting. Emergency coronary artery bypass graft surgery was required in 4.3% (21 of 493 patients). The incidence of in-hospital myocardial infarction (Q wave and non-Q wave) was 5.5% (27 of 493 patients). At 6 months, myocardial infarction was infrequent, occurring in 1.6% (8 of 493 patients). The incidence of in-hospital death was 2.2% (11 of 493 patients). Late death occurred in 7 patients (1.4%) and 34 patients (6.9%) required later bypass graft surgery. Complications included blood loss, primarily from the access site, and subacute thrombosis of the stented vessel in 43 patients (8.7%). Conclusions. The early multicenter experience suggests that this stent is a useful adjunct to coronary angioplasty to prevent or minimize complications associated with flow-limiting coronary artery dissections previously correctable only by surgery. Although this study was not randomized, it demonstrated a high technical success rate and encouraging results with respect to the low incidence of emergency coronary artery bypass graft surgery and myocardial infarction.

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