Multi-energy CT with triple x-ray beams and photon-counting-detector CT for simultaneous imaging of two contrast agents

An experimental comparison

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Multi-energy CT (MECT) enabled by energy-resolved photon-counting-detector CT (PCD-CT) is promising for materialspecific imaging with multiple contrast agents. However, non-idealities of the PCD such as pulse pileup, K-edge escape, and charge sharing may degrade the spectral performance. To perform MECT, an alternative approach was proposed by extending a "Twin Beam" design to a dual-source CT scanner with energy-integrating-detector (EID) by operating one or both sources in the "Twin Beam" mode to acquire three (triple-beam configuration) or four (quadruple-beam configuration) distinct X-ray beam measurements. Previous computer simulation studies demonstrated that the image quality and dose efficiency of the triple-beam configuration were comparable to that in PCD-CT for a three-material decomposition task involving iodine, bismuth, and water. The purpose of this work is to experimentally validate the proposed triple-beam MECT technique in comparison with PCD-CT. To mimic the dual-source triple-beam acquisition, two separate scans, one at 80 kV and the other at 120 kV operated in the "Twin Beam" mode, were performed on a single-source CT scanner. Two potential clinical applications of MECT for multiple contrast agents were investigated: iodine/gadolinium for biphasic liver imaging and iodine/bismuth for small bowel imaging. The results indicate that the imaging performance of the EID-based MECT may be comparable to that on the current PCD-CT platform for both the iodine/gadolinium and the iodine/bismuth material decomposition tasks.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2019
Subtitle of host publicationPhysics of Medical Imaging
EditorsHilde Bosmans, Guang-Hong Chen, Taly Gilat Schmidt
PublisherSPIE
ISBN (Electronic)9781510625433
DOIs
StatePublished - Jan 1 2019
EventMedical Imaging 2019: Physics of Medical Imaging - San Diego, United States
Duration: Feb 17 2019Feb 20 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10948
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2019: Physics of Medical Imaging
CountryUnited States
CitySan Diego
Period2/17/192/20/19

Fingerprint

Photons
Iodine
Contrast Media
counting
Bismuth
X-Rays
Detectors
Imaging techniques
X rays
detectors
photons
iodine
Gadolinium
x rays
bismuth
energy
gadolinium
Decomposition
scanners
Computer Simulation

Keywords

  • Dual-energy CT (DECT)
  • Material Decomposition
  • Multi-energy CT (MECT)
  • Multiple Contrast Agents
  • Photon-counting-detector CT (PCD-CT)

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Ren, L., McCollough, C. H., & Yu, L. (2019). Multi-energy CT with triple x-ray beams and photon-counting-detector CT for simultaneous imaging of two contrast agents: An experimental comparison. In H. Bosmans, G-H. Chen, & T. G. Schmidt (Eds.), Medical Imaging 2019: Physics of Medical Imaging [109481B] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10948). SPIE. https://doi.org/10.1117/12.2513460

Multi-energy CT with triple x-ray beams and photon-counting-detector CT for simultaneous imaging of two contrast agents : An experimental comparison. / Ren, Liqiang; McCollough, Cynthia H; Yu, Lifeng.

Medical Imaging 2019: Physics of Medical Imaging. ed. / Hilde Bosmans; Guang-Hong Chen; Taly Gilat Schmidt. SPIE, 2019. 109481B (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10948).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ren, L, McCollough, CH & Yu, L 2019, Multi-energy CT with triple x-ray beams and photon-counting-detector CT for simultaneous imaging of two contrast agents: An experimental comparison. in H Bosmans, G-H Chen & TG Schmidt (eds), Medical Imaging 2019: Physics of Medical Imaging., 109481B, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10948, SPIE, Medical Imaging 2019: Physics of Medical Imaging, San Diego, United States, 2/17/19. https://doi.org/10.1117/12.2513460
Ren L, McCollough CH, Yu L. Multi-energy CT with triple x-ray beams and photon-counting-detector CT for simultaneous imaging of two contrast agents: An experimental comparison. In Bosmans H, Chen G-H, Schmidt TG, editors, Medical Imaging 2019: Physics of Medical Imaging. SPIE. 2019. 109481B. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2513460
Ren, Liqiang ; McCollough, Cynthia H ; Yu, Lifeng. / Multi-energy CT with triple x-ray beams and photon-counting-detector CT for simultaneous imaging of two contrast agents : An experimental comparison. Medical Imaging 2019: Physics of Medical Imaging. editor / Hilde Bosmans ; Guang-Hong Chen ; Taly Gilat Schmidt. SPIE, 2019. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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