Multi-contrast imaging on dual-source photon-counting-detector (PCD) CT

Shengzhen Tao, Kishore Rajendran, Cynthia H McCollough, Shuai Leng

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Photon-counting-detector (PCD) CT can provide multiple energy bin data sets and allows single-acquisition, multiple-contrast-injection imaging using materials such as iodine, gadolinium and bismuth. However, due to technical limitations, PCDs can suffer from compromised energy-resolving capability, which degrades multicontrast imaging performance. In this work, we investigate the use of a dual-source (DS)-PCD system architecture with additional beam filtration to improve spectral separation among energy bin data sets, and quantify its performance for multi-contrast imaging. Experiments were performed using a CT phantom including various concentrations of iodine (I), gadolinium (Gd) and bismuth (Bi). The DS-PCD architecture was emulated by scanning the same phantom twice on a single-source (SS) PCD-CT with two different tube potentials: 80 kV (energy thresholds = 25/50 keV), and 140 kV (energy thresholds = 25/90 keV) with a 0.4-mm tin filter. We further compared material decomposition performance using the proposed DS-PCD approach with that of the current SS-PCD approach. For the SS-PCD, chess mode with 4 energy bins was used, with energy thresholds of 25/50/75/90 keV to resolve the K-edges of Gd and Bi. The mean energies of the four energy bins in SS-PCD were 72/76/93/109 keV, while those of the four energy bins using DS-PCD were 57/64/88/111 keV, denoting a better spectral separation using DS-PCD. The material quantification root mean square error (RMSE) was reduced from 4.5/3.3/1.2 mg/mL for iodine/Gd/Bi using SS-PCD, to 1.4/1.2/1.1 mg/mL using DS-PCD. These results demonstrate that the DS-PCD can improve multi-contrast imaging performance compared to a SS-PCD acquisition.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2019
Subtitle of host publicationPhysics of Medical Imaging
EditorsHilde Bosmans, Guang-Hong Chen, Taly Gilat Schmidt
ISBN (Electronic)9781510625433
StatePublished - Jan 1 2019
EventMedical Imaging 2019: Physics of Medical Imaging - San Diego, United States
Duration: Feb 17 2019Feb 20 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2019: Physics of Medical Imaging
CountryUnited States
CitySan Diego


  • Computed tomography
  • Multi-contrast imaging
  • Multi-energy CT
  • Photon-counting detectors
  • Spectral CT

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Tao, S., Rajendran, K., McCollough, C. H., & Leng, S. (2019). Multi-contrast imaging on dual-source photon-counting-detector (PCD) CT. In H. Bosmans, G-H. Chen, & T. G. Schmidt (Eds.), Medical Imaging 2019: Physics of Medical Imaging [109484L] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10948). SPIE.