Multi-center genetic study of hypertension: The Family blood pressure program (FBPP)

Eric Boerwinkle; C. Andrew Brown; Maurita Carrejo; Robert Ferrell; Craig Hanis; Richard Hutchinson; Sharon Kardia; Charles Sing; Stephen Turner; Alan Weder; Aravinda Chakravarti; Richard Cooper; Howard Jacob; Nicholas Schork.; Steven Hunt; Donna Arnett; Ingrid Borecki; John Eckfeldt; R. Curtis Ellison; Chi Gu; Gerardo Heiss; Mark Leppert; Albert Oberman; Michael Province; D. C. Rao; David Cox; J. David Curb; Ida Chen; John Grove; Kamal Masaki; Tom Quertermous; Koustubh Ranade; Neil Risch; Beatriz Rodriguez; Stephen Mockrin; Susan Old; Peter Savage

doi:10.1161/hy1201.100415

Multi-center genetic study of hypertension: The Family blood pressure program (FBPP)

Eric Boerwinkle, C. Andrew Brown, Maurita Carrejo, Robert Ferrell, Craig Hanis, Richard Hutchinson, Sharon Kardia, Charles Sing, Stephen Turner, Alan Weder, Aravinda Chakravarti, Richard Cooper, Howard Jacob, Nicholas Schork., Steven Hunt, Donna Arnett, Ingrid Borecki, John Eckfeldt, R. Curtis Ellison, Chi GuGerardo Heiss, Mark Leppert, Albert Oberman, Michael Province, D. C. Rao, David Cox, J. David Curb, Ida Chen, John Grove, Kamal Masaki, Tom Quertermous, Koustubh Ranade, Neil Risch, Beatriz Rodriguez, Stephen Mockrin, Susan Old, Peter Savage

Nephrology and Hypertension

Research output: Contribution to journal › Article › peer-review

161 Scopus citations

Abstract

The Family Blood Pressure Program (FBPP) consists of 4 independently established multicenter networks of investigators who have complementary approaches to the genetics of blood pressure levels and hypertension. The program has recruited participants from the African American, Mexican American, Asian, and non-Hispanic white populations. Each network utilized study designs, laboratory measurements, and analytic methods that made efficient use of the unique characteristics of their populations and the investigators expertise. The individual networks subsequently unified core study components into a single cohesive program. The unified FBPP includes (1) standardized clinic and laboratory protocols for core variables to facilitate direct comparison of results among networks, (2) coordination among laboratories to avoid unnecessary duplication of effort, (3) utilization of a single laboratory for genome-wide marker typing, and (4) a pooled data set containing phenotype and genotype information from > 11 000 individuals.

Original language	English (US)
Pages (from-to)	3-9
Number of pages	7
Journal	Hypertension
Volume	39
Issue number	1
DOIs	https://doi.org/10.1161/hy1201.100415
State	Published - 2002

Keywords

Blood pressure
Genetics
Linkage mapping
Sibling pairs

ASJC Scopus subject areas

Internal Medicine

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10.1161/hy1201.100415

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Boerwinkle, E., Brown, C. A., Carrejo, M., Ferrell, R., Hanis, C., Hutchinson, R., Kardia, S., Sing, C., Turner, S., Weder, A., Chakravarti, A., Cooper, R., Jacob, H., Schork., N., Hunt, S., Arnett, D., Borecki, I., Eckfeldt, J., Ellison, R. C., ... Savage, P. (2002). Multi-center genetic study of hypertension: The Family blood pressure program (FBPP). Hypertension, 39(1), 3-9. https://doi.org/10.1161/hy1201.100415

Boerwinkle, E, Brown, CA, Carrejo, M, Ferrell, R, Hanis, C, Hutchinson, R, Kardia, S, Sing, C, Turner, S, Weder, A, Chakravarti, A, Cooper, R, Jacob, H, Schork., N, Hunt, S, Arnett, D, Borecki, I, Eckfeldt, J, Ellison, RC, Gu, C, Heiss, G, Leppert, M, Oberman, A, Province, M, Rao, DC, Cox, D, Curb, JD, Chen, I, Grove, J, Masaki, K, Quertermous, T, Ranade, K, Risch, N, Rodriguez, B, Mockrin, S, Old, S & Savage, P 2002, 'Multi-center genetic study of hypertension: The Family blood pressure program (FBPP)', Hypertension, vol. 39, no. 1, pp. 3-9. https://doi.org/10.1161/hy1201.100415

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AU - Chen, Ida

AU - Grove, John

AU - Masaki, Kamal

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Multi-center genetic study of hypertension: The Family blood pressure program (FBPP)

Abstract

Keywords

ASJC Scopus subject areas

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