Multi-center genetic study of hypertension: The Family blood pressure program (FBPP)

Eric Boerwinkle, C. Andrew Brown, Maurita Carrejo, Robert Ferrell, Craig Hanis, Richard Hutchinson, Sharon Kardia, Charles Sing, Stephen Turner, Alan Weder, Aravinda Chakravarti, Richard Cooper, Howard Jacob, Nicholas Schork., Steven Hunt, Donna Arnett, Ingrid Borecki, John Eckfeldt, R. Curtis Ellison, Chi GuGerardo Heiss, Mark Leppert, Albert Oberman, Michael Province, D. C. Rao, David Cox, J. David Curb, Ida Chen, John Grove, Kamal Masaki, Tom Quertermous, Koustubh Ranade, Neil Risch, Beatriz Rodriguez, Stephen Mockrin, Susan Old, Peter Savage

Research output: Contribution to journalArticle

158 Scopus citations

Abstract

The Family Blood Pressure Program (FBPP) consists of 4 independently established multicenter networks of investigators who have complementary approaches to the genetics of blood pressure levels and hypertension. The program has recruited participants from the African American, Mexican American, Asian, and non-Hispanic white populations. Each network utilized study designs, laboratory measurements, and analytic methods that made efficient use of the unique characteristics of their populations and the investigators expertise. The individual networks subsequently unified core study components into a single cohesive program. The unified FBPP includes (1) standardized clinic and laboratory protocols for core variables to facilitate direct comparison of results among networks, (2) coordination among laboratories to avoid unnecessary duplication of effort, (3) utilization of a single laboratory for genome-wide marker typing, and (4) a pooled data set containing phenotype and genotype information from > 11 000 individuals.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalHypertension
Volume39
Issue number1
DOIs
StatePublished - Feb 5 2002

Keywords

  • Blood pressure
  • Genetics
  • Linkage mapping
  • Sibling pairs

ASJC Scopus subject areas

  • Internal Medicine

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    Boerwinkle, E., Brown, C. A., Carrejo, M., Ferrell, R., Hanis, C., Hutchinson, R., Kardia, S., Sing, C., Turner, S., Weder, A., Chakravarti, A., Cooper, R., Jacob, H., Schork., N., Hunt, S., Arnett, D., Borecki, I., Eckfeldt, J., Ellison, R. C., ... Savage, P. (2002). Multi-center genetic study of hypertension: The Family blood pressure program (FBPP). Hypertension, 39(1), 3-9. https://doi.org/10.1161/hy1201.100415