TY - JOUR
T1 - Mucosa-associated lymphoid tissue (MALT) lymphoma
T2 - A practical guide for pathologists
AU - Bacon, Chris M.
AU - Du, Ming Qing
AU - Dogan, Ahmet
PY - 2007/4
Y1 - 2007/4
N2 - Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is the third most common non-Hodgkin lymphoma subtype, accounting for around 6-8% of all non-Hodgkin lymphomas in the Western hemisphere. Although MALT lymphomas are clinically indolent, the disease is typically chronic, requiring long-term clinical surveillance and, often, repeated biopsies. Pathologists thus play a central role in the diagnosis and management of these patients. The optimal diagnosis and management of a MALT lymphoma requires careful integration of morphological, immunohistochemical and molecular information, together with close cooperation with the clinician treating the patient. This review discusses recent developments in the molecular pathogenesis of MALT lymphoma and provides strategies for integrating this information into daily pathological practice.
AB - Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is the third most common non-Hodgkin lymphoma subtype, accounting for around 6-8% of all non-Hodgkin lymphomas in the Western hemisphere. Although MALT lymphomas are clinically indolent, the disease is typically chronic, requiring long-term clinical surveillance and, often, repeated biopsies. Pathologists thus play a central role in the diagnosis and management of these patients. The optimal diagnosis and management of a MALT lymphoma requires careful integration of morphological, immunohistochemical and molecular information, together with close cooperation with the clinician treating the patient. This review discusses recent developments in the molecular pathogenesis of MALT lymphoma and provides strategies for integrating this information into daily pathological practice.
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U2 - 10.1136/jcp.2005.031146
DO - 10.1136/jcp.2005.031146
M3 - Review article
C2 - 16950858
AN - SCOPUS:34247126935
SN - 0021-9746
VL - 60
SP - 361
EP - 372
JO - Journal of clinical pathology
JF - Journal of clinical pathology
IS - 4
ER -