Mucoid Pseudomonas in cystic fibrosis

Bobbi Pritt, Linda O'Brien, Washington Winn

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Pseudomonas aeruginosa is a frequent and virulent pulmonary pathogen in patients with cystic fibrosis. If colonization is not prevented, P aeruginosa becomes permanently established and nearly always mutates into a mucoid strain. The alginate-containing matrix of the mucoid strain is thought to allow the formation of protected microcolonies and provide increased resistance to opsonization, phagocytosis, and destruction by antibiotics. As a result, conversion to the mucoid phenotype is associated with a significant increase in morbidity and mortality. In the microbiology laboratory, mucoid P aeruginosa has a distinct Gram stain and culture appearance that can expedite its identification and facilitate appropriate patient management. Important aspects of the mucoid phenotype are reviewed.

Original languageEnglish (US)
Pages (from-to)32-34
Number of pages3
JournalAmerican journal of clinical pathology
Volume128
Issue number1
DOIs
StatePublished - Jul 1 2007

Keywords

  • Culture
  • Cystic fibrosis
  • Gram stain
  • Microbiology
  • Mucoid
  • Pseudomonas

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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