Mucocele-like lesions of the breast: A clinical outcome and histologic analysis of 102 cases

Annie L. Meares, Ryan D. Frank, Amy C Degnim, Robert A. Vierkant, Marlene H. Frost, Lynn C. Hartmann, Stacey J Winham, Daniel W Visscher

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Mucocele-like lesions (MLLs) of the breast are characterized by cystic architecture with stromal mucin and frequent atypia, but it is unknown whether they convey long-term breast cancer risk. We evaluated 102 MLLs that were derived from a single-institution benign breast disease cohort of 13 412 women who underwent biopsy from 1967 to 2001. MLLs were histologically characterized by type of lining epithelium, architecture of the lesion, associated atypical hyperplasia (AH), and incidence of breast cancer (14.8-year median follow-up). A relatively large proportion of MLLs (42%) were diagnosed in women older than 55 years. AH was significantly more frequent in MLL patient compared to the cohort overall (27% versus 5%; P

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalHuman Pathology
Volume49
DOIs
StatePublished - Mar 1 2016

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Mucocele
Breast
Hyperplasia
Breast Neoplasms
Breast Diseases
Mucins
Epithelium
Biopsy
Incidence

Keywords

  • Atypical hyperplasia
  • Benign breast disease
  • Breast carcinoma
  • Columnar cell change
  • Fibrocystic breast disease
  • Mucoele-like lesion

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Mucocele-like lesions of the breast : A clinical outcome and histologic analysis of 102 cases. / Meares, Annie L.; Frank, Ryan D.; Degnim, Amy C; Vierkant, Robert A.; Frost, Marlene H.; Hartmann, Lynn C.; Winham, Stacey J; Visscher, Daniel W.

In: Human Pathology, Vol. 49, 01.03.2016, p. 33-38.

Research output: Contribution to journalArticle

Meares, Annie L. ; Frank, Ryan D. ; Degnim, Amy C ; Vierkant, Robert A. ; Frost, Marlene H. ; Hartmann, Lynn C. ; Winham, Stacey J ; Visscher, Daniel W. / Mucocele-like lesions of the breast : A clinical outcome and histologic analysis of 102 cases. In: Human Pathology. 2016 ; Vol. 49. pp. 33-38.
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