Abstract
MUC1 (MUC1 in humans and Muc1 in nonhuman species) is a transmembrane mucin-like glycoprotein expressed in epithelial cells lining various mucosal surfaces as well as hematopoietic cells. Recently, we showed that Muc1 -/- mice exhibited greater inflammatory responses to Pseudomonas aeruginosa or its flagellin compared with their wild-type littermates, and our studies with cultured cells revealed that MUC1/Muc1 suppressed the Toll-like receptor (TLR) 5 signaling pathway, suggesting its anti-inflammatory role. Here we demonstrate that other TLR signaling (TLR2, 3, 4, 7, and 9) is also suppressed by MUC1/Muc1. The results from this study suggest that MUC1/Muc1 may play a crucial role during airway infection and inflammation by various pathogenic bacteria and viruses.
Original language | English (US) |
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Pages (from-to) | 263-268 |
Number of pages | 6 |
Journal | American journal of respiratory cell and molecular biology |
Volume | 38 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1 2008 |
Keywords
- Anti-inflammatory
- MUC1/Muc1
- NF-κB
- TNF-α
- Toll-like receptors
ASJC Scopus subject areas
- Molecular Biology
- Pulmonary and Respiratory Medicine
- Clinical Biochemistry
- Cell Biology