MUC1 mucin is a negative regulator of toll-like receptor signaling

Keiko Ueno, Takeshi Koga, Kosuke Kato, Douglas T. Golenbock, Sandra J Gendler, Hirofumi Kai, K. Chul Kim

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

MUC1 (MUC1 in humans and Muc1 in nonhuman species) is a transmembrane mucin-like glycoprotein expressed in epithelial cells lining various mucosal surfaces as well as hematopoietic cells. Recently, we showed that Muc1 -/- mice exhibited greater inflammatory responses to Pseudomonas aeruginosa or its flagellin compared with their wild-type littermates, and our studies with cultured cells revealed that MUC1/Muc1 suppressed the Toll-like receptor (TLR) 5 signaling pathway, suggesting its anti-inflammatory role. Here we demonstrate that other TLR signaling (TLR2, 3, 4, 7, and 9) is also suppressed by MUC1/Muc1. The results from this study suggest that MUC1/Muc1 may play a crucial role during airway infection and inflammation by various pathogenic bacteria and viruses.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume38
Issue number3
DOIs
StatePublished - Mar 1 2008

Fingerprint

Toll-Like Receptor 5
Flagellin
Toll-Like Receptors
Mucins
Pseudomonas aeruginosa
Cultured Cells
Glycoproteins
Anti-Inflammatory Agents
Epithelial Cells
Viruses
Inflammation
Bacteria
Infection
Linings
Cells

Keywords

  • Anti-inflammatory
  • MUC1/Muc1
  • NF-κB
  • TNF-α
  • Toll-like receptors

ASJC Scopus subject areas

  • Cell Biology
  • Pulmonary and Respiratory Medicine
  • Molecular Biology

Cite this

MUC1 mucin is a negative regulator of toll-like receptor signaling. / Ueno, Keiko; Koga, Takeshi; Kato, Kosuke; Golenbock, Douglas T.; Gendler, Sandra J; Kai, Hirofumi; Kim, K. Chul.

In: American Journal of Respiratory Cell and Molecular Biology, Vol. 38, No. 3, 01.03.2008, p. 263-268.

Research output: Contribution to journalArticle

Ueno, Keiko ; Koga, Takeshi ; Kato, Kosuke ; Golenbock, Douglas T. ; Gendler, Sandra J ; Kai, Hirofumi ; Kim, K. Chul. / MUC1 mucin is a negative regulator of toll-like receptor signaling. In: American Journal of Respiratory Cell and Molecular Biology. 2008 ; Vol. 38, No. 3. pp. 263-268.
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