MUC1 mucin is a negative regulator of toll-like receptor signaling

Keiko Ueno, Takeshi Koga, Kosuke Kato, Douglas T. Golenbock, Sandra J. Gendler, Hirofumi Kai, K. Chul Kim

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

MUC1 (MUC1 in humans and Muc1 in nonhuman species) is a transmembrane mucin-like glycoprotein expressed in epithelial cells lining various mucosal surfaces as well as hematopoietic cells. Recently, we showed that Muc1 -/- mice exhibited greater inflammatory responses to Pseudomonas aeruginosa or its flagellin compared with their wild-type littermates, and our studies with cultured cells revealed that MUC1/Muc1 suppressed the Toll-like receptor (TLR) 5 signaling pathway, suggesting its anti-inflammatory role. Here we demonstrate that other TLR signaling (TLR2, 3, 4, 7, and 9) is also suppressed by MUC1/Muc1. The results from this study suggest that MUC1/Muc1 may play a crucial role during airway infection and inflammation by various pathogenic bacteria and viruses.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalAmerican journal of respiratory cell and molecular biology
Volume38
Issue number3
DOIs
StatePublished - Mar 1 2008

Keywords

  • Anti-inflammatory
  • MUC1/Muc1
  • NF-κB
  • TNF-α
  • Toll-like receptors

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology

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