mTOR signaling in the differentiation and function of regulatory and effector T cells

Hu Zeng, Hongbo Chi

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

The mechanistic target of rapamycin (mTOR) signaling pathway integrates environmental signals and cellular metabolism to regulate T cell development, activation and differentiation. Recent studies reveal the importance of exquisite control of mTOR activity for proper T cell function, and detailed molecular mechanisms that regulate mTOR signaling in different T cell subsets. Here, we review the latest advances in our understanding of the mTOR pathway and its regulation in the differentiation and function of regulatory T cells and effector T cells.

Original languageEnglish (US)
Pages (from-to)103-111
Number of pages9
JournalCurrent Opinion in Immunology
Volume46
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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