MTOR and lymphocyte metabolism

Hu Zeng, Hongbo Chi

Research output: Contribution to journalReview article

53 Citations (Scopus)

Abstract

Upon antigen engagement and proper co-stimulation, naïve lymphocytes exit quiescence and undergo clonal expansion and differentiate into functional effector cells, after which they either die through apoptosis or survive as memory cells. Lymphocytes at different activation stages exhibit distinct metabolic signatures. Emerging evidence highlights a central role for the mechanistic target of rapamycin (mTOR) in bridging immune signals and metabolic cues to direct lymphocyte proliferation, differentiation and survival. Here we review recent advances in understanding the functional significance and signal transduction of mTOR in T cell biology, and the interplay between mTOR signaling and metabolic programs.

Original languageEnglish (US)
Pages (from-to)347-355
Number of pages9
JournalCurrent Opinion in Immunology
Volume25
Issue number3
DOIs
StatePublished - Jun 1 2013
Externally publishedYes

Fingerprint

Sirolimus
Lymphocytes
Lymphocyte Activation
Cues
Cell Biology
Signal Transduction
Apoptosis
T-Lymphocytes
Antigens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

MTOR and lymphocyte metabolism. / Zeng, Hu; Chi, Hongbo.

In: Current Opinion in Immunology, Vol. 25, No. 3, 01.06.2013, p. 347-355.

Research output: Contribution to journalReview article

Zeng, Hu ; Chi, Hongbo. / MTOR and lymphocyte metabolism. In: Current Opinion in Immunology. 2013 ; Vol. 25, No. 3. pp. 347-355.
@article{51e051964f9f413bb4206b2d9d387f4d,
title = "MTOR and lymphocyte metabolism",
abstract = "Upon antigen engagement and proper co-stimulation, na{\"i}ve lymphocytes exit quiescence and undergo clonal expansion and differentiate into functional effector cells, after which they either die through apoptosis or survive as memory cells. Lymphocytes at different activation stages exhibit distinct metabolic signatures. Emerging evidence highlights a central role for the mechanistic target of rapamycin (mTOR) in bridging immune signals and metabolic cues to direct lymphocyte proliferation, differentiation and survival. Here we review recent advances in understanding the functional significance and signal transduction of mTOR in T cell biology, and the interplay between mTOR signaling and metabolic programs.",
author = "Hu Zeng and Hongbo Chi",
year = "2013",
month = "6",
day = "1",
doi = "10.1016/j.coi.2013.05.002",
language = "English (US)",
volume = "25",
pages = "347--355",
journal = "Current Opinion in Immunology",
issn = "0952-7915",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - MTOR and lymphocyte metabolism

AU - Zeng, Hu

AU - Chi, Hongbo

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Upon antigen engagement and proper co-stimulation, naïve lymphocytes exit quiescence and undergo clonal expansion and differentiate into functional effector cells, after which they either die through apoptosis or survive as memory cells. Lymphocytes at different activation stages exhibit distinct metabolic signatures. Emerging evidence highlights a central role for the mechanistic target of rapamycin (mTOR) in bridging immune signals and metabolic cues to direct lymphocyte proliferation, differentiation and survival. Here we review recent advances in understanding the functional significance and signal transduction of mTOR in T cell biology, and the interplay between mTOR signaling and metabolic programs.

AB - Upon antigen engagement and proper co-stimulation, naïve lymphocytes exit quiescence and undergo clonal expansion and differentiate into functional effector cells, after which they either die through apoptosis or survive as memory cells. Lymphocytes at different activation stages exhibit distinct metabolic signatures. Emerging evidence highlights a central role for the mechanistic target of rapamycin (mTOR) in bridging immune signals and metabolic cues to direct lymphocyte proliferation, differentiation and survival. Here we review recent advances in understanding the functional significance and signal transduction of mTOR in T cell biology, and the interplay between mTOR signaling and metabolic programs.

UR - http://www.scopus.com/inward/record.url?scp=84879195658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879195658&partnerID=8YFLogxK

U2 - 10.1016/j.coi.2013.05.002

DO - 10.1016/j.coi.2013.05.002

M3 - Review article

VL - 25

SP - 347

EP - 355

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

SN - 0952-7915

IS - 3

ER -