MTHFR polymorphisms in relation to ovarian cancer risk

Kathryn L. Terry, Shelley S. Tworoger, Ellen L Goode, Margaret A. Gates, Linda Titus-Ernstoff, Linda E. Kelemen, Thomas A. Sellers, Susan E. Hankinson, Daniel W. Cramer

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: Folate has been hypothesized to influence carcinogenesis due to its dual role in DNA methylation, which regulates gene expression, and synthesis of purine and thymidylate, which is vital for DNA repair. Thus, we examined ovarian cancer risk in relation to two functional polymorphisms (C677T and A1298C) in the MTHFR gene. Methods: We genotyped the C677T (rs1801133) and A1298C (rs1801131) MTHFR polymorphisms in 1642 cases and 2068 controls from three studies, the New England Case Control Study (NEC), Nurses' Health Study (NHS), and Mayo Clinic Ovarian Cancer Case Control Study (MAY). Results: Overall, we observed no association between either SNP and ovarian cancer risk (pooled C677T ptrend = 0.59 and A1298C ptrend = 0.58). Significant associations (C677T ptrend = 0.001, A1298C p trend = 0.02) between these MTHFR SNPs and serous ovarian cancer risk were observed in the NEC study, but were not replicated in the NHS and MAY studies. Conclusions: MTHFR SNPs C677T and A1298C are not associated with ovarian cancer risk. Our results highlight the need for validation of genetic findings.

Original languageEnglish (US)
Pages (from-to)319-324
Number of pages6
JournalGynecologic Oncology
Volume119
Issue number2
DOIs
StatePublished - Nov 2010

Fingerprint

Ovarian Neoplasms
Single Nucleotide Polymorphism
Case-Control Studies
Nurses
New England
Health
DNA Methylation
Folic Acid
DNA Repair
Carcinogenesis
Gene Expression
Genes

Keywords

  • Folate
  • MTHFR
  • Ovarian cancer
  • Polymorphism

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Terry, K. L., Tworoger, S. S., Goode, E. L., Gates, M. A., Titus-Ernstoff, L., Kelemen, L. E., ... Cramer, D. W. (2010). MTHFR polymorphisms in relation to ovarian cancer risk. Gynecologic Oncology, 119(2), 319-324. https://doi.org/10.1016/j.ygyno.2010.08.007

MTHFR polymorphisms in relation to ovarian cancer risk. / Terry, Kathryn L.; Tworoger, Shelley S.; Goode, Ellen L; Gates, Margaret A.; Titus-Ernstoff, Linda; Kelemen, Linda E.; Sellers, Thomas A.; Hankinson, Susan E.; Cramer, Daniel W.

In: Gynecologic Oncology, Vol. 119, No. 2, 11.2010, p. 319-324.

Research output: Contribution to journalArticle

Terry, KL, Tworoger, SS, Goode, EL, Gates, MA, Titus-Ernstoff, L, Kelemen, LE, Sellers, TA, Hankinson, SE & Cramer, DW 2010, 'MTHFR polymorphisms in relation to ovarian cancer risk', Gynecologic Oncology, vol. 119, no. 2, pp. 319-324. https://doi.org/10.1016/j.ygyno.2010.08.007
Terry KL, Tworoger SS, Goode EL, Gates MA, Titus-Ernstoff L, Kelemen LE et al. MTHFR polymorphisms in relation to ovarian cancer risk. Gynecologic Oncology. 2010 Nov;119(2):319-324. https://doi.org/10.1016/j.ygyno.2010.08.007
Terry, Kathryn L. ; Tworoger, Shelley S. ; Goode, Ellen L ; Gates, Margaret A. ; Titus-Ernstoff, Linda ; Kelemen, Linda E. ; Sellers, Thomas A. ; Hankinson, Susan E. ; Cramer, Daniel W. / MTHFR polymorphisms in relation to ovarian cancer risk. In: Gynecologic Oncology. 2010 ; Vol. 119, No. 2. pp. 319-324.
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