MRS in Mild Cognitive Impairment: Early Differentiation of Dementia with Lewy Bodies and Alzheimer's Disease

Bing Zhang, Tanis J. Ferman, Bradley F. Boeve, Glenn E. Smith, Mandie Maroney-Smith, Anthony J. Spychalla, David S. Knopman, Clifford R. Jack, Ronald C. Petersen, Kejal Kantarci

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Mild cognitive impairment (MCI) precedes both Alzheimer's disease (AD) dementia and with Lewy bodies (DLB). We investigated proton magnetic resonance spectroscopy (MRS) characteristics of MCI patients who progressed to DLB compared to those who progressed to AD dementia or remained stable. METHODS: Consecutive MCI patients who underwent single voxel MRS at baseline and progressed to DLB (n = 10) were identified during a median follow-up period of 18 months. From the same cohort, we identified age- and sex-matched MCI patients who progressed to AD dementia (n = 27) or remained stable (n = 20) during a similar follow-up period. This study was approved by the Institutional Review Board and informed consent was from every subject. RESULTS: MCI patients who progressed to AD dementia were characterized by lower N-acetylaspartate (NAA)/Cr ratio in the posterior cingulate voxel compared to those who progressed to DLB (P = .001). Decreased NAA/Cr in the posterior cingulate voxel differentiated MCI patients who progressed to DLB from those who progressed to AD with an area under the receiver operating characteristic curve of .85 (P < .001) on logistic regression analysis. CONCLUSIONS: MRS may be useful in differentiating MCI patients with prodromal AD dementia from those with prodromal DLB for early disease-specific interventions.

Original languageEnglish (US)
Pages (from-to)269-274
Number of pages6
JournalJournal of Neuroimaging
Volume25
Issue number2
DOIs
StatePublished - Mar 1 2015

Keywords

  • Alzheimer's disease
  • Dementia with lewy bodies (DLB)
  • MRI
  • Magnetic resonance spectroscopy (MRS)
  • Mild cognitive impairment (MCI)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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