mRNA expression of the four isoforms of the human plasma membrane Ca2+-ATPase in the human hippocampus

David A. Zacharias, Steven J. DeMarco, Emanuel E. Strehler

Research output: Contribution to journalArticle

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Abstract

Ca2+ dyshomeostasis is a contributing factor to the development and progression of neurodegenerative disease. Plasma membrane Ca2+-ATPases (PMCAs) are responsible for setting intracellular Ca2+ levels and may be involved in the dynamic processing of Ca2+ loads in normal and pathological conditions. In situ hybridization was employed to determine the expression pattern of the four human PMCA isoforms in the human hippocampus. PMCA1 and 3 mRNAs were weakly expressed throughout the hippocampal formation, whereas PMCA2 and 4 mRNA expression showed distinct regional differences, with increased levels in CA2 and the dentate gyrus. Differential expression of PMCA isoforms may reflect cellular differences in Ca2+-handling properties and provide a partial explanation for the differential susceptibility of hippocampal neurons to Ca2+-mediated cell death.

Original languageEnglish (US)
Pages (from-to)173-176
Number of pages4
JournalMolecular Brain Research
Volume45
Issue number1
DOIs
StatePublished - Apr 1 1997

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Keywords

  • Calcium homeostasis
  • Hippocampus
  • Hybridization, in situ
  • Neuronal cell death
  • Plasma membrane calcium ATPase

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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