MRI of transforaminal lumbar interbody fusion: Imaging appearance with and without the use of human recombinant bone morphogenetic protein-2 (rhBMP-2)

Michael Fox, Judd M. Goldberg, Cree M. Gaskin, Michelle S. Barr, James T. Patrie, Francis H. Shen, Bennett Alford

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To describe the vertebral endplate and intervertebral disc space MRI appearance following TLIF, with and without the use of rhBMP-2, and to determine if the appearance is concerning for discitis/osteomyelitis. Materials and methods: After institutional review board approval, 116 TLIF assessments performed on 75 patients with rhBMP-2 were retrospectively and independently reviewed by five radiologists and compared to 73 TLIF assessments performed on 45 patients without rhBMP-2. MRIs were evaluated for endplate signal, disc space enhancement, disc space fluid, and abnormal paraspinal soft tissue. Endplate edema-like signal was reported when T1-weighted hypointensity, T2-weighted hyperintensity, and endplate enhancement were present. Subjective concern for discitis/osteomyelitis on MRI was graded on a five-point scale. Generalized estimating equation binomial regression model analysis was performed with findings correlated with rhBMP-2 use, TLIF level, graft type, and days between TLIF and MRI. Results: The rhBMP-2 group demonstrated endplate edema-like signal (OR 5.66; 95 % CI [1.58, 20.24], p=0.008) and disc space enhancement (OR 2.40; 95 % CI [1.20, 4.80], p=0.013) more often after adjusting for the TLIF level, graft type, and the number of days following TLIF. Both groups had a similar temporal distribution for endplate edema-like signal but disc space enhancement peaked earlier in the rhBMP-2 group. Disc space fluid was only present in the rhBMP-2 group. Neither group demonstrated abnormal paraspinal soft tissue and discitis/osteomyelitis was not considered likely in any patient. Conclusions: Endplate edema-like signal and disc space enhancement were significantly more frequent and disc space enhancement developed more rapidly following TLIF when rhBMP-2 was utilized. The concern for discitis/osteomyelitis was similar and minimal in both groups.

Original languageEnglish (US)
Pages (from-to)1247-1255
Number of pages9
JournalSkeletal Radiology
Volume43
Issue number9
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Discitis
Osteomyelitis
Edema
Transplants
Intervertebral Disc
Research Ethics Committees
Statistical Models
Regression Analysis
recombinant human bone morphogenetic protein-2

Keywords

  • Human bone morphogenetic protein-2 (rhBMP-2)
  • Lumbar spine
  • MRI
  • Post-operative
  • Translumbar interbody fusion (TLIF)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

MRI of transforaminal lumbar interbody fusion : Imaging appearance with and without the use of human recombinant bone morphogenetic protein-2 (rhBMP-2). / Fox, Michael; Goldberg, Judd M.; Gaskin, Cree M.; Barr, Michelle S.; Patrie, James T.; Shen, Francis H.; Alford, Bennett.

In: Skeletal Radiology, Vol. 43, No. 9, 01.01.2014, p. 1247-1255.

Research output: Contribution to journalArticle

Fox, Michael ; Goldberg, Judd M. ; Gaskin, Cree M. ; Barr, Michelle S. ; Patrie, James T. ; Shen, Francis H. ; Alford, Bennett. / MRI of transforaminal lumbar interbody fusion : Imaging appearance with and without the use of human recombinant bone morphogenetic protein-2 (rhBMP-2). In: Skeletal Radiology. 2014 ; Vol. 43, No. 9. pp. 1247-1255.
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abstract = "Purpose: To describe the vertebral endplate and intervertebral disc space MRI appearance following TLIF, with and without the use of rhBMP-2, and to determine if the appearance is concerning for discitis/osteomyelitis. Materials and methods: After institutional review board approval, 116 TLIF assessments performed on 75 patients with rhBMP-2 were retrospectively and independently reviewed by five radiologists and compared to 73 TLIF assessments performed on 45 patients without rhBMP-2. MRIs were evaluated for endplate signal, disc space enhancement, disc space fluid, and abnormal paraspinal soft tissue. Endplate edema-like signal was reported when T1-weighted hypointensity, T2-weighted hyperintensity, and endplate enhancement were present. Subjective concern for discitis/osteomyelitis on MRI was graded on a five-point scale. Generalized estimating equation binomial regression model analysis was performed with findings correlated with rhBMP-2 use, TLIF level, graft type, and days between TLIF and MRI. Results: The rhBMP-2 group demonstrated endplate edema-like signal (OR 5.66; 95 {\%} CI [1.58, 20.24], p=0.008) and disc space enhancement (OR 2.40; 95 {\%} CI [1.20, 4.80], p=0.013) more often after adjusting for the TLIF level, graft type, and the number of days following TLIF. Both groups had a similar temporal distribution for endplate edema-like signal but disc space enhancement peaked earlier in the rhBMP-2 group. Disc space fluid was only present in the rhBMP-2 group. Neither group demonstrated abnormal paraspinal soft tissue and discitis/osteomyelitis was not considered likely in any patient. Conclusions: Endplate edema-like signal and disc space enhancement were significantly more frequent and disc space enhancement developed more rapidly following TLIF when rhBMP-2 was utilized. The concern for discitis/osteomyelitis was similar and minimal in both groups.",
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T2 - Imaging appearance with and without the use of human recombinant bone morphogenetic protein-2 (rhBMP-2)

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AU - Goldberg, Judd M.

AU - Gaskin, Cree M.

AU - Barr, Michelle S.

AU - Patrie, James T.

AU - Shen, Francis H.

AU - Alford, Bennett

PY - 2014/1/1

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N2 - Purpose: To describe the vertebral endplate and intervertebral disc space MRI appearance following TLIF, with and without the use of rhBMP-2, and to determine if the appearance is concerning for discitis/osteomyelitis. Materials and methods: After institutional review board approval, 116 TLIF assessments performed on 75 patients with rhBMP-2 were retrospectively and independently reviewed by five radiologists and compared to 73 TLIF assessments performed on 45 patients without rhBMP-2. MRIs were evaluated for endplate signal, disc space enhancement, disc space fluid, and abnormal paraspinal soft tissue. Endplate edema-like signal was reported when T1-weighted hypointensity, T2-weighted hyperintensity, and endplate enhancement were present. Subjective concern for discitis/osteomyelitis on MRI was graded on a five-point scale. Generalized estimating equation binomial regression model analysis was performed with findings correlated with rhBMP-2 use, TLIF level, graft type, and days between TLIF and MRI. Results: The rhBMP-2 group demonstrated endplate edema-like signal (OR 5.66; 95 % CI [1.58, 20.24], p=0.008) and disc space enhancement (OR 2.40; 95 % CI [1.20, 4.80], p=0.013) more often after adjusting for the TLIF level, graft type, and the number of days following TLIF. Both groups had a similar temporal distribution for endplate edema-like signal but disc space enhancement peaked earlier in the rhBMP-2 group. Disc space fluid was only present in the rhBMP-2 group. Neither group demonstrated abnormal paraspinal soft tissue and discitis/osteomyelitis was not considered likely in any patient. Conclusions: Endplate edema-like signal and disc space enhancement were significantly more frequent and disc space enhancement developed more rapidly following TLIF when rhBMP-2 was utilized. The concern for discitis/osteomyelitis was similar and minimal in both groups.

AB - Purpose: To describe the vertebral endplate and intervertebral disc space MRI appearance following TLIF, with and without the use of rhBMP-2, and to determine if the appearance is concerning for discitis/osteomyelitis. Materials and methods: After institutional review board approval, 116 TLIF assessments performed on 75 patients with rhBMP-2 were retrospectively and independently reviewed by five radiologists and compared to 73 TLIF assessments performed on 45 patients without rhBMP-2. MRIs were evaluated for endplate signal, disc space enhancement, disc space fluid, and abnormal paraspinal soft tissue. Endplate edema-like signal was reported when T1-weighted hypointensity, T2-weighted hyperintensity, and endplate enhancement were present. Subjective concern for discitis/osteomyelitis on MRI was graded on a five-point scale. Generalized estimating equation binomial regression model analysis was performed with findings correlated with rhBMP-2 use, TLIF level, graft type, and days between TLIF and MRI. Results: The rhBMP-2 group demonstrated endplate edema-like signal (OR 5.66; 95 % CI [1.58, 20.24], p=0.008) and disc space enhancement (OR 2.40; 95 % CI [1.20, 4.80], p=0.013) more often after adjusting for the TLIF level, graft type, and the number of days following TLIF. Both groups had a similar temporal distribution for endplate edema-like signal but disc space enhancement peaked earlier in the rhBMP-2 group. Disc space fluid was only present in the rhBMP-2 group. Neither group demonstrated abnormal paraspinal soft tissue and discitis/osteomyelitis was not considered likely in any patient. Conclusions: Endplate edema-like signal and disc space enhancement were significantly more frequent and disc space enhancement developed more rapidly following TLIF when rhBMP-2 was utilized. The concern for discitis/osteomyelitis was similar and minimal in both groups.

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KW - Lumbar spine

KW - MRI

KW - Post-operative

KW - Translumbar interbody fusion (TLIF)

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