MRI in the presurgical evaluation of patients with frontal lobe epilepsy and children with temporal lobe epilepsy: pathologic correlation and prognostic importance

Gregory D Cascino, Clifford R Jr. Jack, Joseph E Parisi, W. Richard Marsh, Patrick J. Kelly, Frank W. Sharbrough, Kathryn A. Hirschorn, Max R. Trenerry

Research output: Contribution to journalArticle

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Abstract

We performed magnetic resonance imaging (MRI) using a high-field strength magnet (1.5 T) in two series of 53 patients with intractable partial epilepsy of frontal lobe or temporal lobe origin who subsequently received ablative surgery for their seizure disorder. In the first series of patients the pathologic correlation and prognostic importance of an MRI-identified lesion in the frontal lobe were assessed. Twenty-five percent of the patients with negative MRI studies and 67% of patients with neuroimaging abnormalities restricted to the frontal lobe, were seizure-free at a minimum duration of follow-up of 1 year. None of the patients with a multilobar MRI-detected abnormality was seizure-free postoperatively. In the second study the sensitivity and specificity of MRI-based hippocampal volumetry was determined in pediatric patients with partial epilepsy of temporal lobe origin unrelated to foreign-tissue pathology. Hippocampal formation atrophy in the epileptic temporal lobe was identified in 63% of patients. The sensitivity and specificity of hippocampal volumetry was 100% in patients with mesial temporal sclerosis. The presence of an MRI-detected epileptogenic lesion in the frontal lobe and hippocampal formation atrophy in the temporal lobe may correlate with the underlying pathology and affect the identification of potential candidates for epilepsy surgery.

Original languageEnglish (US)
Pages (from-to)51-59
Number of pages9
JournalEpilepsy Research
Volume11
Issue number1
DOIs
StatePublished - 1992

Fingerprint

Frontal Lobe Epilepsy
Temporal Lobe Epilepsy
Magnetic Resonance Imaging
Frontal Lobe
Temporal Lobe
Partial Epilepsy
Atrophy
Epilepsy
Hippocampus
Seizures
Pathology
Sensitivity and Specificity
Magnets
Sclerosis
Neuroimaging
Pediatrics

Keywords

  • Epilepsy surgery
  • Frontal lobe
  • Hippocampal volumetry
  • MRI
  • Partial epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

MRI in the presurgical evaluation of patients with frontal lobe epilepsy and children with temporal lobe epilepsy : pathologic correlation and prognostic importance. / Cascino, Gregory D; Jack, Clifford R Jr.; Parisi, Joseph E; Marsh, W. Richard; Kelly, Patrick J.; Sharbrough, Frank W.; Hirschorn, Kathryn A.; Trenerry, Max R.

In: Epilepsy Research, Vol. 11, No. 1, 1992, p. 51-59.

Research output: Contribution to journalArticle

Cascino, Gregory D ; Jack, Clifford R Jr. ; Parisi, Joseph E ; Marsh, W. Richard ; Kelly, Patrick J. ; Sharbrough, Frank W. ; Hirschorn, Kathryn A. ; Trenerry, Max R. / MRI in the presurgical evaluation of patients with frontal lobe epilepsy and children with temporal lobe epilepsy : pathologic correlation and prognostic importance. In: Epilepsy Research. 1992 ; Vol. 11, No. 1. pp. 51-59.
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