MRI hippocampal volumes and memory function before and after temporal lobectomy

M. R. Trenerry, C. R. Jack, R. J. Ivnik, F. W. Sharbrough, G. D. Cascino, K. A. Hirschorn, W. R. Marsh, P. J. Kelly, F. B. Meyer

Research output: Contribution to journalArticle

286 Scopus citations

Abstract

We investigated the relationship between preoperative MRI hippocampal volumes and clinical neuropsychological memory test data obtained before and after temporal lobectomy and amygdalohippocampectomy for intractable epilepsy in 44 left (LTL) and 36 right (RTL) temporal lobectomy patients. In LTL patients, the difference (right minus left hippocampal volume) between hippocampal volumes (DHF) was significantly (p < 0.001) correlated (r = 0.61) with postoperative verbal memory change as measured by a delayed memory percent retention score from the Wechsler Memory Scale-Revised, Logical Memory subtest. DHF was also positively associated with postoperative memory for abstract geometric designs in LTL patients (r = 0.49, p < 0.005). Resection of a relatively nonatrophic left hippocampus was associated with poorer verbal and visual memory outcome. In RTL patients, larger right adjusted (for total intracranial volume) hippocampal volume was associated with decline in visual-spatial learning, but not memory, following surgery MRI hippocampal volume data appear to provide meaningful information in evaluating the risk for memory impairment following temporal lobectomy.

Original languageEnglish (US)
Pages (from-to)1800-1805
Number of pages6
JournalNeurology
Volume43
Issue number9
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Clinical Neurology

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    Trenerry, M. R., Jack, C. R., Ivnik, R. J., Sharbrough, F. W., Cascino, G. D., Hirschorn, K. A., Marsh, W. R., Kelly, P. J., & Meyer, F. B. (1993). MRI hippocampal volumes and memory function before and after temporal lobectomy. Neurology, 43(9), 1800-1805. https://doi.org/10.1212/wnl.43.9.1800