MRI findings of disc degeneration are more prevalent in adults with low back pain than in asymptomatic controls: A systematic review and meta-analysis

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Abstract

BACKGROUND AND PURPOSE: Imaging features of spine degeneration are common in symptomatic and asymptomatic individuals. We compared the prevalence of MR imaging features of lumbar spine degeneration in adults 50 years of age and younger with and without self-reported low back pain. MATERIALS AND METHODS: We performed a meta-analysis of studies reporting the prevalence of degenerative lumbar spine MR imaging findings in asymptomatic and symptomatic adults 50 years of age or younger. Symptomatic individuals had axial low back pain with or without radicular symptoms. Two reviewers evaluated each article for the following outcomes: disc bulge, disc degeneration, disc extrusion, disc protrusion, annular fissures, Modic 1 changes, any Modic changes, central canal stenosis, spondylolisthesis, and spondylolysis. The meta-analysis was performed by using a random-effects model. RESULTS: An initial search yielded 280 unique studies. Fourteen (5.0%) met the inclusion criteria (3097 individuals; 1193, 38.6%, asymptomatic; 1904, 61.4%, symptomatic). Imaging findings with a higher prevalence in symptomatic individuals 50 years of age or younger included disc bulge (OR, 7.54; 95% CI, 1.28-44.56; P <.03), spondylolysis (OR, 5.06; 95% CI, 1.65-15.53; P = .01), disc extrusion (OR, 4.38; 95% CI, 1.98-9.68; P = .01), Modic 1 changes (OR, 4.01; 95% CI, 1.10-14.55; P <.04), disc protrusion (OR, 2.65; 95% CI, 1.52-4.62; P = .01), and disc degeneration (OR, 2.24; 95% CI, 1.21-4.15, P

Original languageEnglish (US)
Pages (from-to)2394-2399
Number of pages6
JournalAmerican Journal of Neuroradiology
Volume36
Issue number12
DOIs
StatePublished - Dec 1 2015

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Intervertebral Disc Degeneration
Low Back Pain
Spondylolysis
Meta-Analysis
Spine
Spondylolisthesis
Pathologic Constriction
Cross-Sectional Studies

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

Cite this

@article{90555f5d716c4f69bc7a5032252f690d,
title = "MRI findings of disc degeneration are more prevalent in adults with low back pain than in asymptomatic controls: A systematic review and meta-analysis",
abstract = "BACKGROUND AND PURPOSE: Imaging features of spine degeneration are common in symptomatic and asymptomatic individuals. We compared the prevalence of MR imaging features of lumbar spine degeneration in adults 50 years of age and younger with and without self-reported low back pain. MATERIALS AND METHODS: We performed a meta-analysis of studies reporting the prevalence of degenerative lumbar spine MR imaging findings in asymptomatic and symptomatic adults 50 years of age or younger. Symptomatic individuals had axial low back pain with or without radicular symptoms. Two reviewers evaluated each article for the following outcomes: disc bulge, disc degeneration, disc extrusion, disc protrusion, annular fissures, Modic 1 changes, any Modic changes, central canal stenosis, spondylolisthesis, and spondylolysis. The meta-analysis was performed by using a random-effects model. RESULTS: An initial search yielded 280 unique studies. Fourteen (5.0{\%}) met the inclusion criteria (3097 individuals; 1193, 38.6{\%}, asymptomatic; 1904, 61.4{\%}, symptomatic). Imaging findings with a higher prevalence in symptomatic individuals 50 years of age or younger included disc bulge (OR, 7.54; 95{\%} CI, 1.28-44.56; P <.03), spondylolysis (OR, 5.06; 95{\%} CI, 1.65-15.53; P = .01), disc extrusion (OR, 4.38; 95{\%} CI, 1.98-9.68; P = .01), Modic 1 changes (OR, 4.01; 95{\%} CI, 1.10-14.55; P <.04), disc protrusion (OR, 2.65; 95{\%} CI, 1.52-4.62; P = .01), and disc degeneration (OR, 2.24; 95{\%} CI, 1.21-4.15, P",
author = "Waleed Brinjikji and Diehn, {F. E.} and Jarvik, {J. G.} and Carrie Carr and Kallmes, {David F} and Murad, {Mohammad H} and Luetmer, {Patrick H}",
year = "2015",
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T1 - MRI findings of disc degeneration are more prevalent in adults with low back pain than in asymptomatic controls

T2 - A systematic review and meta-analysis

AU - Brinjikji, Waleed

AU - Diehn, F. E.

AU - Jarvik, J. G.

AU - Carr, Carrie

AU - Kallmes, David F

AU - Murad, Mohammad H

AU - Luetmer, Patrick H

PY - 2015/12/1

Y1 - 2015/12/1

N2 - BACKGROUND AND PURPOSE: Imaging features of spine degeneration are common in symptomatic and asymptomatic individuals. We compared the prevalence of MR imaging features of lumbar spine degeneration in adults 50 years of age and younger with and without self-reported low back pain. MATERIALS AND METHODS: We performed a meta-analysis of studies reporting the prevalence of degenerative lumbar spine MR imaging findings in asymptomatic and symptomatic adults 50 years of age or younger. Symptomatic individuals had axial low back pain with or without radicular symptoms. Two reviewers evaluated each article for the following outcomes: disc bulge, disc degeneration, disc extrusion, disc protrusion, annular fissures, Modic 1 changes, any Modic changes, central canal stenosis, spondylolisthesis, and spondylolysis. The meta-analysis was performed by using a random-effects model. RESULTS: An initial search yielded 280 unique studies. Fourteen (5.0%) met the inclusion criteria (3097 individuals; 1193, 38.6%, asymptomatic; 1904, 61.4%, symptomatic). Imaging findings with a higher prevalence in symptomatic individuals 50 years of age or younger included disc bulge (OR, 7.54; 95% CI, 1.28-44.56; P <.03), spondylolysis (OR, 5.06; 95% CI, 1.65-15.53; P = .01), disc extrusion (OR, 4.38; 95% CI, 1.98-9.68; P = .01), Modic 1 changes (OR, 4.01; 95% CI, 1.10-14.55; P <.04), disc protrusion (OR, 2.65; 95% CI, 1.52-4.62; P = .01), and disc degeneration (OR, 2.24; 95% CI, 1.21-4.15, P

AB - BACKGROUND AND PURPOSE: Imaging features of spine degeneration are common in symptomatic and asymptomatic individuals. We compared the prevalence of MR imaging features of lumbar spine degeneration in adults 50 years of age and younger with and without self-reported low back pain. MATERIALS AND METHODS: We performed a meta-analysis of studies reporting the prevalence of degenerative lumbar spine MR imaging findings in asymptomatic and symptomatic adults 50 years of age or younger. Symptomatic individuals had axial low back pain with or without radicular symptoms. Two reviewers evaluated each article for the following outcomes: disc bulge, disc degeneration, disc extrusion, disc protrusion, annular fissures, Modic 1 changes, any Modic changes, central canal stenosis, spondylolisthesis, and spondylolysis. The meta-analysis was performed by using a random-effects model. RESULTS: An initial search yielded 280 unique studies. Fourteen (5.0%) met the inclusion criteria (3097 individuals; 1193, 38.6%, asymptomatic; 1904, 61.4%, symptomatic). Imaging findings with a higher prevalence in symptomatic individuals 50 years of age or younger included disc bulge (OR, 7.54; 95% CI, 1.28-44.56; P <.03), spondylolysis (OR, 5.06; 95% CI, 1.65-15.53; P = .01), disc extrusion (OR, 4.38; 95% CI, 1.98-9.68; P = .01), Modic 1 changes (OR, 4.01; 95% CI, 1.10-14.55; P <.04), disc protrusion (OR, 2.65; 95% CI, 1.52-4.62; P = .01), and disc degeneration (OR, 2.24; 95% CI, 1.21-4.15, P

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