MRI-based thermometry and thermal dosimetry during focused ultrasound thermal ablation of uterine leiomyomas

Nathan McDannold, Clare Tempany, Elizabeth A. Stewart, Ferenc A. Jolesz, Kullervo Hynynen

Research output: Contribution to journalConference article

Abstract

MRI-based temperature imaging and thermal dosimetry were tested during focused ultrasound treatments of uterine leiomyomas (fibroids). Imaging data from the treatments of 62 fibroids in 50 women were analyzed to test the ability of thermal dose maps acquired during treatment to predict the resulting non-perfused area in contrast-enhanced images acquired immediately after treatment. Also, the variation in the peak temperature rise achieved was compared between patients and between sonications within treatments. On average, the non-perfused area was 1.9 ± 0.7 times as large as the area that achieved a thermal dose of 240 equivalent min at 43°C. The non-perfused area agreed better with a lower threshold; it was 1.2 ± 0.4 times as large as the area that achieved a thermal dose of ≥ 18 equivalent min at 43°C Agreement was better for smaller treatments. For large treatments at least, the non-perfused area was clearly enlarged by vascular occlusion to regions within the fibroid that were outside that directly targeted. Variations in the peak temperature rise were as large as a factor of two for similar acoustic parameters, both between patients and within individual treatments. These results demonstrate the need and usefulness of quantitative temperature mapping during focused ultrasound surgery.

Original languageEnglish (US)
Article numberU6-F-1
Pages (from-to)705-708
Number of pages4
JournalProceedings - IEEE Ultrasonics Symposium
Volume1
StatePublished - Dec 1 2004
Event2004 IEEE Ultrasonics Symposium - Montreal, Que., Canada
Duration: Aug 23 2004Aug 27 2004

Keywords

  • MRI thermometry
  • Ultrasound therapy
  • Uterine leiomyomas

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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