MR of mandibular invasion in patients with oral and oropharyngeal malignant neoplasms

Sub Chung Tae Sub Chung, D. M. Yousem, H. M. Seigerman, B. N. Schlakman, G. S. Weinstein, Richard E Hayden

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

PURPOSE: To investigate whether MR imaging is an accurate means of assessing mandibular invasion in patients with carcinoma. METHODS: We retrospectively studied the MR scans of 22 patients with pathologic or surgical confirmation of mandibular invasion from oral and oropharyngeal cancers. The MR images were blindly analyzed using primary criteria of: (a) cortical breakdown, (b) replacement of bone marrow fat, or (c) gadopentetate dimeglumine enhancement of a mass at the bone marrow defect. Secondary criteria of: (a) contiguous soft-tissue mass, and (b) mass on both sides of the mandibular cortex were also examined. Mandibular invasion was graded as periosteal/cortical, medullary, or no invasion. RESULTS: Primary positive findings of cortical breakdown and abnormal bone marrow signal were highly sensitive (100%) for periosteal/cortical invasion and medullary involvement, respectively. However, a high rate of false-positive studies hampered the MR accuracy, which fell into the 73% to 77% range. A negative MR study was highly predictive, but a positive study was less valuable. Gadolinium enhancement added little to the MR study's accuracy. False-positive studies mainly occurred in the setting of prior irradiation, osteoradionecrosis, and odontogenic infections. CONCLUSIONS: MR imaging is a sensitive method for detecting mandibular invasion but has a low positive predictive value. A negative study virtually excludes cortical/periosteal or bone marrow invasion.

Original languageEnglish (US)
Pages (from-to)1949-1955
Number of pages7
JournalAmerican Journal of Neuroradiology
Volume15
Issue number10
StatePublished - 1994
Externally publishedYes

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Oropharyngeal Neoplasms
Bone Marrow
Osteoradionecrosis
Gadolinium DTPA
Mouth Neoplasms
Gadolinium
Fats
Carcinoma
Infection

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Tae Sub Chung, S. C., Yousem, D. M., Seigerman, H. M., Schlakman, B. N., Weinstein, G. S., & Hayden, R. E. (1994). MR of mandibular invasion in patients with oral and oropharyngeal malignant neoplasms. American Journal of Neuroradiology, 15(10), 1949-1955.

MR of mandibular invasion in patients with oral and oropharyngeal malignant neoplasms. / Tae Sub Chung, Sub Chung; Yousem, D. M.; Seigerman, H. M.; Schlakman, B. N.; Weinstein, G. S.; Hayden, Richard E.

In: American Journal of Neuroradiology, Vol. 15, No. 10, 1994, p. 1949-1955.

Research output: Contribution to journalArticle

Tae Sub Chung, SC, Yousem, DM, Seigerman, HM, Schlakman, BN, Weinstein, GS & Hayden, RE 1994, 'MR of mandibular invasion in patients with oral and oropharyngeal malignant neoplasms', American Journal of Neuroradiology, vol. 15, no. 10, pp. 1949-1955.
Tae Sub Chung SC, Yousem DM, Seigerman HM, Schlakman BN, Weinstein GS, Hayden RE. MR of mandibular invasion in patients with oral and oropharyngeal malignant neoplasms. American Journal of Neuroradiology. 1994;15(10):1949-1955.
Tae Sub Chung, Sub Chung ; Yousem, D. M. ; Seigerman, H. M. ; Schlakman, B. N. ; Weinstein, G. S. ; Hayden, Richard E. / MR of mandibular invasion in patients with oral and oropharyngeal malignant neoplasms. In: American Journal of Neuroradiology. 1994 ; Vol. 15, No. 10. pp. 1949-1955.
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abstract = "PURPOSE: To investigate whether MR imaging is an accurate means of assessing mandibular invasion in patients with carcinoma. METHODS: We retrospectively studied the MR scans of 22 patients with pathologic or surgical confirmation of mandibular invasion from oral and oropharyngeal cancers. The MR images were blindly analyzed using primary criteria of: (a) cortical breakdown, (b) replacement of bone marrow fat, or (c) gadopentetate dimeglumine enhancement of a mass at the bone marrow defect. Secondary criteria of: (a) contiguous soft-tissue mass, and (b) mass on both sides of the mandibular cortex were also examined. Mandibular invasion was graded as periosteal/cortical, medullary, or no invasion. RESULTS: Primary positive findings of cortical breakdown and abnormal bone marrow signal were highly sensitive (100{\%}) for periosteal/cortical invasion and medullary involvement, respectively. However, a high rate of false-positive studies hampered the MR accuracy, which fell into the 73{\%} to 77{\%} range. A negative MR study was highly predictive, but a positive study was less valuable. Gadolinium enhancement added little to the MR study's accuracy. False-positive studies mainly occurred in the setting of prior irradiation, osteoradionecrosis, and odontogenic infections. CONCLUSIONS: MR imaging is a sensitive method for detecting mandibular invasion but has a low positive predictive value. A negative study virtually excludes cortical/periosteal or bone marrow invasion.",
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T1 - MR of mandibular invasion in patients with oral and oropharyngeal malignant neoplasms

AU - Tae Sub Chung, Sub Chung

AU - Yousem, D. M.

AU - Seigerman, H. M.

AU - Schlakman, B. N.

AU - Weinstein, G. S.

AU - Hayden, Richard E

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N2 - PURPOSE: To investigate whether MR imaging is an accurate means of assessing mandibular invasion in patients with carcinoma. METHODS: We retrospectively studied the MR scans of 22 patients with pathologic or surgical confirmation of mandibular invasion from oral and oropharyngeal cancers. The MR images were blindly analyzed using primary criteria of: (a) cortical breakdown, (b) replacement of bone marrow fat, or (c) gadopentetate dimeglumine enhancement of a mass at the bone marrow defect. Secondary criteria of: (a) contiguous soft-tissue mass, and (b) mass on both sides of the mandibular cortex were also examined. Mandibular invasion was graded as periosteal/cortical, medullary, or no invasion. RESULTS: Primary positive findings of cortical breakdown and abnormal bone marrow signal were highly sensitive (100%) for periosteal/cortical invasion and medullary involvement, respectively. However, a high rate of false-positive studies hampered the MR accuracy, which fell into the 73% to 77% range. A negative MR study was highly predictive, but a positive study was less valuable. Gadolinium enhancement added little to the MR study's accuracy. False-positive studies mainly occurred in the setting of prior irradiation, osteoradionecrosis, and odontogenic infections. CONCLUSIONS: MR imaging is a sensitive method for detecting mandibular invasion but has a low positive predictive value. A negative study virtually excludes cortical/periosteal or bone marrow invasion.

AB - PURPOSE: To investigate whether MR imaging is an accurate means of assessing mandibular invasion in patients with carcinoma. METHODS: We retrospectively studied the MR scans of 22 patients with pathologic or surgical confirmation of mandibular invasion from oral and oropharyngeal cancers. The MR images were blindly analyzed using primary criteria of: (a) cortical breakdown, (b) replacement of bone marrow fat, or (c) gadopentetate dimeglumine enhancement of a mass at the bone marrow defect. Secondary criteria of: (a) contiguous soft-tissue mass, and (b) mass on both sides of the mandibular cortex were also examined. Mandibular invasion was graded as periosteal/cortical, medullary, or no invasion. RESULTS: Primary positive findings of cortical breakdown and abnormal bone marrow signal were highly sensitive (100%) for periosteal/cortical invasion and medullary involvement, respectively. However, a high rate of false-positive studies hampered the MR accuracy, which fell into the 73% to 77% range. A negative MR study was highly predictive, but a positive study was less valuable. Gadolinium enhancement added little to the MR study's accuracy. False-positive studies mainly occurred in the setting of prior irradiation, osteoradionecrosis, and odontogenic infections. CONCLUSIONS: MR imaging is a sensitive method for detecting mandibular invasion but has a low positive predictive value. A negative study virtually excludes cortical/periosteal or bone marrow invasion.

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