Mr imaging in comatose survivors of cardiac resuscitation

E. F M Wijdicks, Norbert G Campeau, G. M. Miller

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: The prognosis of comatose survivors is determined by clinical examination. Early laboratory indicators of poor prognosis (such as evoked potentials) have low sensitivity. The role of MR imaging as a confirmatory study was investigated. METHODS: We studied fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted (DW) imaging in 10 patients comatose after cardiac arrest. RESULTS: None of the 10 comatose patients had myoclonus status epilepticus or fixed, dilated pupils on neurologic examination, and none had abnormal somatosensory-evoked potentials. Eight patients showed diffuse signal abnormalities, predominantly in the cerebellum (n = 5), the thalamus (n = 8), the frontal and parietal cortices (n = 8), and the hippocampus (n = 9). One patient showed normal MR imaging results, and one patient had abnormalities in the thalamus and cerebellum and minimal abnormality on DW images; both later awakened. None of the patients with abnormal cortical structures on FLAIR MR images recovered beyond a severely disabled state. CONCLUSION: MR imaging in comatose survivors may parallel the pathologic findings in severe anoxic-ischemic injury, and extensive abnormalities may indicate little to no prospects for recovery. If confirmed, MR imaging may have a role as a prognosticating test in anoxicischemic coma.

Original languageEnglish (US)
Pages (from-to)1561-1565
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume22
Issue number8
StatePublished - 2001

Fingerprint

Coma
Resuscitation
Survivors
Thalamus
Cerebellum
Pupil Disorders
Parietal Lobe
Myoclonus
Somatosensory Evoked Potentials
Status Epilepticus
Neurologic Examination
Frontal Lobe
Heart Arrest
Evoked Potentials
Hippocampus
Wounds and Injuries

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Mr imaging in comatose survivors of cardiac resuscitation. / Wijdicks, E. F M; Campeau, Norbert G; Miller, G. M.

In: American Journal of Neuroradiology, Vol. 22, No. 8, 2001, p. 1561-1565.

Research output: Contribution to journalArticle

Wijdicks, E. F M ; Campeau, Norbert G ; Miller, G. M. / Mr imaging in comatose survivors of cardiac resuscitation. In: American Journal of Neuroradiology. 2001 ; Vol. 22, No. 8. pp. 1561-1565.
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