MR imaging-guided focused ultrasound surgery of uterine leiomyomas

A feasibility study

C. M C Tempany, Elizabeth A Stewart, Nathan McDannold, Bradley J. Quade, Ferenc A. Jolesz, Kullervo Hynynen

Research output: Contribution to journalArticle

457 Citations (Scopus)

Abstract

The feasibility and safety of magnetic resonance (MR) imaging-guided focused ultrasound surgery for uterine leiomyomas is reported. Sequential sonications were delivered to nine targets. Temperature-sensitive phase-difference MR imaging monitored the location of the focus and measured tissue temperature elevations, ensuring therapeutic dose. MR images and hysterectomy specimens were evaluated. Six leiomyomas received full therapeutic doses, and 98.5% of the sonications were visualized. MR thermometry was successful in all sonications and cases. Focal necrotic lesions were seen in all cases at MR, and five were pathologically confirmed. MR imaging-guided focused ultrasound causes thermocoagulation and necrosis in uterine leiomyomas and is feasible and safe, without serious consequences.

Original languageEnglish (US)
Pages (from-to)897-905
Number of pages9
JournalRadiology
Volume226
Issue number3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

Fingerprint

Sonication
Leiomyoma
Feasibility Studies
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Thermometry
Electrocoagulation
Temperature
Hysterectomy
Necrosis
Safety
Therapeutics

Keywords

  • Leiomyoma
  • Magnetic resonance (MR), thermometry
  • Ultrasound (US), focused
  • Ultrasound (US), therapeutic
  • Uterine neoplasms, MR
  • Uterine neoplasms, US

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Tempany, C. M. C., Stewart, E. A., McDannold, N., Quade, B. J., Jolesz, F. A., & Hynynen, K. (2003). MR imaging-guided focused ultrasound surgery of uterine leiomyomas: A feasibility study. Radiology, 226(3), 897-905. https://doi.org/10.1148/radiol.2271020395

MR imaging-guided focused ultrasound surgery of uterine leiomyomas : A feasibility study. / Tempany, C. M C; Stewart, Elizabeth A; McDannold, Nathan; Quade, Bradley J.; Jolesz, Ferenc A.; Hynynen, Kullervo.

In: Radiology, Vol. 226, No. 3, 01.03.2003, p. 897-905.

Research output: Contribution to journalArticle

Tempany, CMC, Stewart, EA, McDannold, N, Quade, BJ, Jolesz, FA & Hynynen, K 2003, 'MR imaging-guided focused ultrasound surgery of uterine leiomyomas: A feasibility study', Radiology, vol. 226, no. 3, pp. 897-905. https://doi.org/10.1148/radiol.2271020395
Tempany, C. M C ; Stewart, Elizabeth A ; McDannold, Nathan ; Quade, Bradley J. ; Jolesz, Ferenc A. ; Hynynen, Kullervo. / MR imaging-guided focused ultrasound surgery of uterine leiomyomas : A feasibility study. In: Radiology. 2003 ; Vol. 226, No. 3. pp. 897-905.
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