MR imaging-guided focused ultrasound surgery of uterine leiomyomas: A feasibility study

Clare M.C. Tempany; Elizabeth A. Stewart; Nathan McDannold; Bradley J. Quade; Ferenc A. Jolesz; Kullervo Hynynen

doi:10.1148/radiol.2271020395

MR imaging-guided focused ultrasound surgery of uterine leiomyomas: A feasibility study

Clare M.C. Tempany, Elizabeth A. Stewart, Nathan McDannold, Bradley J. Quade, Ferenc A. Jolesz, Kullervo Hynynen

Obstetrics/Gynecology

Research output: Contribution to journal › Article › peer-review

486 Scopus citations

Abstract

The feasibility and safety of magnetic resonance (MR) imaging-guided focused ultrasound surgery for uterine leiomyomas is reported. Sequential sonications were delivered to nine targets. Temperature-sensitive phase-difference MR imaging monitored the location of the focus and measured tissue temperature elevations, ensuring therapeutic dose. MR images and hysterectomy specimens were evaluated. Six leiomyomas received full therapeutic doses, and 98.5% of the sonications were visualized. MR thermometry was successful in all sonications and cases. Focal necrotic lesions were seen in all cases at MR, and five were pathologically confirmed. MR imaging-guided focused ultrasound causes thermocoagulation and necrosis in uterine leiomyomas and is feasible and safe, without serious consequences.

Original language	English (US)
Pages (from-to)	897-905
Number of pages	9
Journal	Radiology
Volume	226
Issue number	3
DOIs	https://doi.org/10.1148/radiol.2271020395
State	Published - Mar 1 2003

Keywords

Leiomyoma
Magnetic resonance (MR), thermometry
Ultrasound (US), focused
Ultrasound (US), therapeutic
Uterine neoplasms, MR
Uterine neoplasms, US

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1148/radiol.2271020395

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title = "MR imaging-guided focused ultrasound surgery of uterine leiomyomas: A feasibility study",

abstract = "The feasibility and safety of magnetic resonance (MR) imaging-guided focused ultrasound surgery for uterine leiomyomas is reported. Sequential sonications were delivered to nine targets. Temperature-sensitive phase-difference MR imaging monitored the location of the focus and measured tissue temperature elevations, ensuring therapeutic dose. MR images and hysterectomy specimens were evaluated. Six leiomyomas received full therapeutic doses, and 98.5% of the sonications were visualized. MR thermometry was successful in all sonications and cases. Focal necrotic lesions were seen in all cases at MR, and five were pathologically confirmed. MR imaging-guided focused ultrasound causes thermocoagulation and necrosis in uterine leiomyomas and is feasible and safe, without serious consequences.",

keywords = "Leiomyoma, Magnetic resonance (MR), thermometry, Ultrasound (US), focused, Ultrasound (US), therapeutic, Uterine neoplasms, MR, Uterine neoplasms, US",

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AU - Tempany, Clare M.C.

AU - Stewart, Elizabeth A.

AU - McDannold, Nathan

AU - Quade, Bradley J.

AU - Jolesz, Ferenc A.

AU - Hynynen, Kullervo

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AB - The feasibility and safety of magnetic resonance (MR) imaging-guided focused ultrasound surgery for uterine leiomyomas is reported. Sequential sonications were delivered to nine targets. Temperature-sensitive phase-difference MR imaging monitored the location of the focus and measured tissue temperature elevations, ensuring therapeutic dose. MR images and hysterectomy specimens were evaluated. Six leiomyomas received full therapeutic doses, and 98.5% of the sonications were visualized. MR thermometry was successful in all sonications and cases. Focal necrotic lesions were seen in all cases at MR, and five were pathologically confirmed. MR imaging-guided focused ultrasound causes thermocoagulation and necrosis in uterine leiomyomas and is feasible and safe, without serious consequences.

KW - Leiomyoma

KW - Magnetic resonance (MR), thermometry

KW - Ultrasound (US), focused

KW - Ultrasound (US), therapeutic

KW - Uterine neoplasms, MR

KW - Uterine neoplasms, US

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MR imaging-guided focused ultrasound surgery of uterine leiomyomas: A feasibility study

Abstract

Keywords

ASJC Scopus subject areas

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