MR elastography of the lung with hyperpolarized 3He

Kiaran P. McGee, Rolf D. Hubmayr, R. L. Ehman

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

MR elastography (MRE) is a phase contrast-based technique for spatially mapping the mechanical properties of tissue-like materials. While hyperpolarized noble gases such as helium-3 (3He) have proven to be an ideal contrast mechanism for imaging of the lung using conventional MR techniques, their applicability for lung MRE is unknown, due to the fact that gases do not support shear. In this study, we report on the application of MRE to an ex vivo porcine lung specimen inflated with a hyperpolarized noble gas. Unlike proton MRE, shear wave propagation is encoded into the gas entrapped within the alveolar spaces rather than the parenchyma itself. These data provide first evidence of the technical feasibility of MRE of the lung using hyperpolarized noble gases.

Original languageEnglish (US)
Pages (from-to)14-18
Number of pages5
JournalMagnetic Resonance in Medicine
Volume59
Issue number1
DOIs
StatePublished - Jan 2008

Keywords

  • Helium-3
  • Hyperpolarized
  • Lungs
  • Magnetic resonance elastography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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