MR elastography of the in vivo abdominal aorta: A feasibility study for comparing aortic stiffness between hypertensives and normotensives

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Purpose: To demonstrate feasibility of using MR elastography (MRE) to identify hypertensive changes in the abdominal aorta when compared with normotensives based on the stiffness measurements. Materials and Methods: MRE was performed on eight volunteers (four normotensives and four hypertensives) to measure the effective stiffness of the abdominal aorta. MRE wave images are directionally filtered and phase gradient analysis was performed to determine the stiffness of the aorta. Student's t-test was performed to determine significant difference in stiffness measurements between normotensives and hypertensives. Results: The normotensive group demonstrated a mean abdominal aortic stiffness of 3.7 ± 0.8 kPa, while the controlled-hypertensive demonstrated a mean abdominal aortic stiffness of 9.3 ± 1.9 kPa. MRE effective stiffness of abdominal aorta in hypertensives was significantly greater than that of normotensives with p = 0.02. Conclusion: Feasibility of in vivo aortic MRE is demonstrated. Hypertensives have significantly higher aortic stiffness assessed through MRE than normotensives.

Original languageEnglish (US)
Pages (from-to)582-586
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume35
Issue number3
DOIs
StatePublished - Mar 2012

Fingerprint

Elasticity Imaging Techniques
Vascular Stiffness
Abdominal Aorta
Feasibility Studies
Aorta
Volunteers
Students

Keywords

  • aortic MRE
  • aortic stiffness
  • hypertension
  • MR elastography
  • MRE

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{962eeef2b3ee4bcf87fc7896227ad302,
title = "MR elastography of the in vivo abdominal aorta: A feasibility study for comparing aortic stiffness between hypertensives and normotensives",
abstract = "Purpose: To demonstrate feasibility of using MR elastography (MRE) to identify hypertensive changes in the abdominal aorta when compared with normotensives based on the stiffness measurements. Materials and Methods: MRE was performed on eight volunteers (four normotensives and four hypertensives) to measure the effective stiffness of the abdominal aorta. MRE wave images are directionally filtered and phase gradient analysis was performed to determine the stiffness of the aorta. Student's t-test was performed to determine significant difference in stiffness measurements between normotensives and hypertensives. Results: The normotensive group demonstrated a mean abdominal aortic stiffness of 3.7 ± 0.8 kPa, while the controlled-hypertensive demonstrated a mean abdominal aortic stiffness of 9.3 ± 1.9 kPa. MRE effective stiffness of abdominal aorta in hypertensives was significantly greater than that of normotensives with p = 0.02. Conclusion: Feasibility of in vivo aortic MRE is demonstrated. Hypertensives have significantly higher aortic stiffness assessed through MRE than normotensives.",
keywords = "aortic MRE, aortic stiffness, hypertension, MR elastography, MRE",
author = "Arunark Kolipaka and Woodrum, {David A} and Araoz, {Philip A} and Ehman, {Richard Lorne}",
year = "2012",
month = "3",
doi = "10.1002/jmri.22866",
language = "English (US)",
volume = "35",
pages = "582--586",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - MR elastography of the in vivo abdominal aorta

T2 - A feasibility study for comparing aortic stiffness between hypertensives and normotensives

AU - Kolipaka, Arunark

AU - Woodrum, David A

AU - Araoz, Philip A

AU - Ehman, Richard Lorne

PY - 2012/3

Y1 - 2012/3

N2 - Purpose: To demonstrate feasibility of using MR elastography (MRE) to identify hypertensive changes in the abdominal aorta when compared with normotensives based on the stiffness measurements. Materials and Methods: MRE was performed on eight volunteers (four normotensives and four hypertensives) to measure the effective stiffness of the abdominal aorta. MRE wave images are directionally filtered and phase gradient analysis was performed to determine the stiffness of the aorta. Student's t-test was performed to determine significant difference in stiffness measurements between normotensives and hypertensives. Results: The normotensive group demonstrated a mean abdominal aortic stiffness of 3.7 ± 0.8 kPa, while the controlled-hypertensive demonstrated a mean abdominal aortic stiffness of 9.3 ± 1.9 kPa. MRE effective stiffness of abdominal aorta in hypertensives was significantly greater than that of normotensives with p = 0.02. Conclusion: Feasibility of in vivo aortic MRE is demonstrated. Hypertensives have significantly higher aortic stiffness assessed through MRE than normotensives.

AB - Purpose: To demonstrate feasibility of using MR elastography (MRE) to identify hypertensive changes in the abdominal aorta when compared with normotensives based on the stiffness measurements. Materials and Methods: MRE was performed on eight volunteers (four normotensives and four hypertensives) to measure the effective stiffness of the abdominal aorta. MRE wave images are directionally filtered and phase gradient analysis was performed to determine the stiffness of the aorta. Student's t-test was performed to determine significant difference in stiffness measurements between normotensives and hypertensives. Results: The normotensive group demonstrated a mean abdominal aortic stiffness of 3.7 ± 0.8 kPa, while the controlled-hypertensive demonstrated a mean abdominal aortic stiffness of 9.3 ± 1.9 kPa. MRE effective stiffness of abdominal aorta in hypertensives was significantly greater than that of normotensives with p = 0.02. Conclusion: Feasibility of in vivo aortic MRE is demonstrated. Hypertensives have significantly higher aortic stiffness assessed through MRE than normotensives.

KW - aortic MRE

KW - aortic stiffness

KW - hypertension

KW - MR elastography

KW - MRE

UR - http://www.scopus.com/inward/record.url?scp=84857080089&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857080089&partnerID=8YFLogxK

U2 - 10.1002/jmri.22866

DO - 10.1002/jmri.22866

M3 - Article

C2 - 22045617

AN - SCOPUS:84857080089

VL - 35

SP - 582

EP - 586

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 3

ER -