MR elastography of the human abdominal aorta: A preliminary study

Lei Xu, Jun Chen, Kevin J. Glaser, Meng Yin, Phillip J. Rossman, Richard Lorne Ehman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: To investigate the feasibility of using MR elastography (MRE) for the evaluation of the stiffness of in vivo aortic wall. Materials and Methods: To validate the experimental approach for imaging the aorta in vivo, a gel phantom with an embedded porcine aorta was imaged in the presence of fluid flow within the aorta. The potential changes in the elasticity of the vessel wall with changes in pressure were investigated. The feasibility of performing MRE of abdominal aorta was assessed in five volunteers (age, 22-40 years; body mass index, 21.5-25.2 kg/m2). The pulse-gated cine MRE technique was used to study the wave propagation along the aorta throughout the cardiac cycle and provide estimates of aortic stiffness in diastole. Results: In the phantom study, the wave propagation was well visualized within the porcine aorta embedded in the gel phantom. An increase of the Young's modulus-wall thickness (E*t) product with the increase in static pressure was observed. In the in vivo study, the waves were well visualized within the lumen of abdominal aorta in the five volunteers in diastolic phase, but they were not well visualized during systole. Conclusion: MRE is feasible for noninvasively assessing the stiffness of the abdominal aorta and merits further investigation.

Original languageEnglish (US)
Pages (from-to)1549-1553
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume38
Issue number6
DOIs
StatePublished - Dec 2013

Fingerprint

Elasticity Imaging Techniques
Abdominal Aorta
Aorta
Volunteers
Swine
Gels
Pressure
Vascular Stiffness
Diastole
Elastic Modulus
Systole
Elasticity
Pulse
Body Mass Index

Keywords

  • aorta
  • elastography
  • MRI
  • stiffness

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

MR elastography of the human abdominal aorta : A preliminary study. / Xu, Lei; Chen, Jun; Glaser, Kevin J.; Yin, Meng; Rossman, Phillip J.; Ehman, Richard Lorne.

In: Journal of Magnetic Resonance Imaging, Vol. 38, No. 6, 12.2013, p. 1549-1553.

Research output: Contribution to journalArticle

Xu, Lei ; Chen, Jun ; Glaser, Kevin J. ; Yin, Meng ; Rossman, Phillip J. ; Ehman, Richard Lorne. / MR elastography of the human abdominal aorta : A preliminary study. In: Journal of Magnetic Resonance Imaging. 2013 ; Vol. 38, No. 6. pp. 1549-1553.
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